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Repulsive Scaling Replica Exchange Molecular Dynamics in Modeling Protein-Glycosaminoglycan Complexes
Glycosaminoglycans are long linear periodic anionic polysaccharides consisting of disaccharide units exhibiting different sulfation patterns forming...
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Biological Networks
In several areas of biology, networks are frequently employed to conveniently describe interactions between relevant biological components....
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Distribution of Glycolipids in the Plasma Membrane Monitored by Specific Probes in Combination with Sodium Dodecyl Sulfate-Digested Freeze-Fracture Replica Labeling (SDS-FRL)
Glycolipids are mainly distributed in the outer leaflet of the plasma membrane and are involved in cellular signaling by modulating the activity of...
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All-Atom Molecular Dynamics Simulation Methods for the Aggregation of Protein and Peptides: Replica Exchange/Permutation and Nonequilibrium Simulations
Protein aggregates are associated with more than 40 serious human diseases. To understand the formation mechanism of protein aggregates at atomic...
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Brevibacillus laterosporus as a Biological Control Agent
AbstractThe article analyzes and summarizes the literary and own results of studies of the properties of Brevibacillus laterosporus ( Bl ) as an agent...
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Long-term impact of wildfire on soil physical, chemical and biological properties within a pine forest
Anthropogenic fires pose a serious threat to many terrestrial ecosystems because they can cause loss of biodiversity and carbon stocks in the...
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Testing 3D printed biological platform for advancing simulated microgravity and space mechanobiology research
The advancement of microgravity simulators is hel** many researchers better understanding the impact of the mechanically unloaded space environment...
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Visualization of Peptidoglycan Structures of Escherichia coli by Quick-Freeze Deep-Etch Electron Microscopy
Peptidoglycan (PG) is an essential component of the bacterial cell wall that protects the cell from turgor pressure and maintains its shape. In...
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Design and Fabrication of Biological Wires for Cardiac Fibrosis Disease Modeling
Extensive progress has been made in develo** engineered models for elucidating human cardiac disease. Cardiac fibrosis is often associated with all...
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Freeze-Fracture Replica Immunolabeling of Cryopreserved Membrane Compartments, Cultured Cells and Tissues
Membrane topology information and views of membrane-embedded protein complexes promote our understanding of membrane organization and cell biological...
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Combination of furosemide, gold, and dopamine as a potential therapy for breast cancer
Breast cancer is one of the leading causes of death in women worldwide. Initially, it develops in the epithelium of the ducts or lobules of the...
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Human immunocompetent choroid-on-chip: a novel tool for studying ocular effects of biological drugs
Disorders of the eye leading to visual impairment are a major issue that affects millions of people. On the other side ocular toxicities were...
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Artificial intelligence assisted identification of potential tau aggregation inhibitors: ligand- and structure-based virtual screening, in silico ADME, and molecular dynamics study
Alzheimer’s disease (AD) is a severe, growing, multifactorial disorder affecting millions of people worldwide characterized by cognitive decline and...
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Modeling the Structure, Dynamics, and Transformations of Proteins with the UNRES Force Field
The physics-based united-residue (UNRES) model of proteins ( www.unres.pl ) has been designed to carry...
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Biological Control of Penicillium on Lemon Fruits by Essential Oils of Satureja Species
Essential oils obtained from stem plus leaves of six Satureja species ( Satureja cilicica, Satureja cuneifolia, Satureja hortensis, Satureja montana,...
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Replica-Exchange Methods for Biomolecular Simulations
In this study, a replica-exchange method was developed to overcome conformational sampling difficulties in computer simulations of spin glass or...
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Molecular Simulations Guidelines for Biological Nanomaterials: From Peptides to Membranes
In studying biological processes and focusing on the molecular mechanisms at the basis of these, molecular dynamics (MD) simulations have...
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Microfabricated Devices for Confocal Microscopy on Biological Samples
Microfabricated devices have found applications in a range of biomedical research problems in recent years, with thousands of research papers...
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From Quantum Mechanics, Classical Mechanics, and Bioinformatics to Artificial Intelligence Studies in Neurodegenerative Diseases
The amyloid β-protein is an intrinsically disordered protein that has the potential to assemble into myriad structures, including oligomers and...
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Multi-omics profiling of CSF from spinal muscular atrophy type 3 patients after nusinersen treatment: a 2-year follow-up multicenter retrospective study
Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by mutations in the SMN1 gene resulting in reduced levels of the SMN protein....
