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Anchor Clustering for million-scale immune repertoire sequencing data
BackgroundThe clustering of immune repertoire data is challenging due to the computational cost associated with a very large number of pairwise...
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Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition
Gene expression during natural and induced reprogramming is controlled by pioneer transcription factors that initiate transcription from closed...
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CAGNet: an improved anchor-free method for shrimp larvae detection in intensive aquaculture
Object detection adopting deep-learning has strongly promoted the development of intensive aquaculture. However, shrimp larvae, as an important...
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Anchor-based bisulfite sequencing determines genome-wide DNA methylation
Whole Genome Bisulfite Sequencing (WGBS) is the current standard for DNA methylation profiling. However, this approach is costly as it requires...
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An Arg/Ala-rich helix in the N-terminal region of M. tuberculosis FtsQ is a potential membrane anchor of the Z-ring
Mtb infects a quarter of the worldwide population. Most drugs for treating tuberculosis target cell growth and division. With rising drug resistance,...
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A novel, non-GMO surface display in Limosilactobacillus fermentum mediated by cell surface hydrolase without anchor motif
Recent studies have demonstrated the potential of surface display technology in therapeutic development and enzyme immobilization. Utilization of...
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Anchor Away: A System for Fast Inhibition of Proteins in Drosophila
Anchor away is a sequestering method designed to acutely and timely abrogate the function of a protein of interest by anchoring to a cell compartment...
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An RNA-Ligation-Based RACE-PAT Assay to Monitor Poly(A) Tail Length of mRNAs of Interest
In eukaryotes, a non-templated poly-adenosine (poly(A)) tail is added co-transcriptionally to almost every messenger RNA (mRNA). The length of this...
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Full-length isoform concatenation sequencing to resolve cancer transcriptome complexity
BackgroundCancers exhibit complex transcriptomes with aberrant splicing that induces isoform-level differential expression compared to non-diseased...
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The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin’s...
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Chromosome-length genome assembly of Teladorsagia circumcincta – a globally important helminth parasite in livestock
BackgroundGastrointestinal (GIT) helminthiasis is a global problem that affects livestock health, especially in small ruminants. One of the major...
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PIP2 determines length and stability of primary cilia by balancing membrane turnovers
Primary cilia are sensory organelles on many postmitotic cells. The ciliary membrane is continuous with the plasma membrane but differs in its...
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New and previously described species of Ameloblastella (Monogenoidea: Dactylogyridae) parasitizing Hypophthalmus marginatus and Pimelodina flavipinnis (Siluriformes: Pimelodidae) from the Tocantins River, Maranhão State, Brazil
A new and two previously described species of Ameloblastella Kritsky, Mendoza-Franco & Scholz, 2000 were found in the gills of two pimelodid...
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Benchmarking full-length transcript single cell mRNA sequencing protocols
BackgroundSingle cell mRNA sequencing technologies have transformed our understanding of cellular heterogeneity and identity. For sensitive discovery...
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Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and conformation
B-cell lymphoma 2 (Bcl-2) proteins are the main regulators of mitochondrial apoptosis. Anti-apoptotic Bcl-2 proteins possess a hydrophobic...
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A survey of transcriptome complexity using full-length isoform sequencing in the tea plant Camellia sinensis
Tea is one of the most popular beverages and its leaves are rich in catechins, contributing to the diverse flavor as well as beneficial for human...
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Genome-wide association study reveals the genetic architecture of root hair length in maize
BackgroundRoot hair, a special type of tubular-shaped cell, outgrows from root epidermal cell and plays important roles in the acquisition of...
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Limits of piriform silk adhesion—similar effects of substrate surface polarity on silk anchor performance in two spider species with disparate microhabitat use
It has been suggested that physical interactions between biological and environmental surfaces may constrain ecological niche spaces. However, the...
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Whole-cell catalytic synthesis of trehalose by Corynebacterium glutamicum displaying trehalose synthase on its cell surface
Trehalose is a disaccharide with many applications in cosmetics, refrigeration, and food. Trehalose synthase is a significant enzyme in trehalose...
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Strategies to display heterologous proteins on the cell surface of lactic acid bacteria using as anchor the C-terminal domain of Lactobacillus acidophilus SlpA
AbstractThe surface-layer (S-layer) protein of Lactobacillus acidophilus is a crystalline array of self-assembling subunits, non-covalently bound to...
