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Engineering of Yeast Glycoprotein Expression
Yeasts are valuable hosts for recombinant protein production, as these unicellular eukaryotes are easy to handle, grow rapidly to a high cell density...
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Structural Basis of Protein Asn-Glycosylation by Oligosaccharyltransferases
Glycosylation of asparagine residues is a ubiquitous protein modification. This N-glycosylation is essential in Eukaryotes, but principally...
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Generation and degradation of free asparagine-linked glycans
Asparagine ( N )-linked protein glycosylation, which takes place in the eukaryotic endoplasmic reticulum (ER), is important for protein folding,...
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N-glycoprotein macroheterogeneity: biological implications and proteomic characterization
Glycosylation is a co- and post-translational modification that is critical for the regulation of the biophysical properties and biological...
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Progress in Yeast Glycosylation Engineering
While yeast are lower eukaryotic organisms, they share many common features and biological processes with higher eukaryotes. As such, yeasts have...
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Improvement of N-glycan site occupancy of therapeutic glycoproteins produced in Pichia pastoris
Yeast is capable of performing posttranslational modifications, such as N - or O -glycosylation. It has been demonstrated that N -glycans play critical...
