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Fmo induction as a tool to screen for pro-longevity drugs
Dietary restriction (DR) and hypoxia (low oxygen) extend lifespan in Caenorhabditis elegans through the induction of a convergent downstream...
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Probing the interaction of new and biologically active Pd(II) complex with DNA/BSA via joint experimental and computational studies along with thermodynamic, NLO, FMO and NBO analysis
Treatment with transition metal complexes is an efficient method to fight with cancer. Therefore, a new transition metal complex formulated as [Pd(1,...
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Improving sulforaphane content in transgenic broccoli plants by overexpressing MAM1, FMOGS–OX2, and Myrosinase
Sulforaphane (SF) is a potential secondary metabolite with anticancer activity and its metabolic pathway has been revealed in the model plant Arabidops...
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Exploring marine-derived bioactive compounds for dual inhibition of Pseudomonas aeruginosa LpxA and LpxD: integrated bioinformatics and cheminformatics approaches
Pseudomonas aeruginosa can cause serious nosocomial infections. Targeting the biosynthesis of Lipid A, a major structural domain of...
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Identification of natural product as selective PI3Kα inhibitor against NSCLC: multi-ligand pharmacophore modeling, molecular docking, ADME, DFT, and MD simulations
Non-small cell lung cancer (NSCLC) is a widespread and often aggressive form of cancer affecting people worldwide. PIK3CA missense mutations play a...
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Metabolism of an insecticide fipronil by soil fungus Cunninghamella elegans ATCC36112
In this study, the metabolic pathway of the phenylpyrazole insecticide fipronil in Cunninghamella elegans ( C. elegans ) was investigated....
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High Performance Computing for Drug Discovery and Biomedicine
This volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The...
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The influence of quaternary structure on the stability of Fenna–Matthews–Olson (FMO) antenna complexes
The trimeric nature of the Fenna–Matthews–Olson (FMO) protein antenna complex from green sulfur phototrophic bacteria was investigated. Mutations...
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High-Throughput Structure-Based Drug Design (HT-SBDD) Using Drug Docking, Fragment Molecular Orbital Calculations, and Molecular Dynamic Techniques
Structure-based drug design (SBDD) is rapidly evolving to be a fundamental tool for faster and more cost-effective methods of lead drug discovery....
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Data Analysis
Chapter 12 focuses on analyzing cytometric data, considering immunophenotypic analyses and DNA analysis separately. The first part of the chapter...
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Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue
Macrophages are one of the prominent leukocyte populations in white adipose tissue (WAT) and play an important role during WAT homeostasis and...
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Interaction Between Macrophages and Cryptococcus neoformans: Distinguishing Phagocytosed Versus External Fungi
The interaction between macrophages and Cryptococcus neoformans is crucial in the pathogenesis of cryptococcosis. These phagocytes are important...
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Identification of novel flavin-dependent monooxygenase from Strobilanthes Cusia reveals molecular basis of indoles’ biosynthetic logic
BackgroundStrobilanthes cusia (Nees) Kuntze is a traditional medical plant distributed widely in south China. The indole compounds that originated...
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Isolation and Flow Cytometry Analysis of Macrophages from the Kidney
Renal macrophages help maintain homeostasis, participate in tissue injury and repair, and play a vital role in immune surveillance [1–3]. Kidney...
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Hematopoietic Stem Cell Identification Postirradiation
Radiation exposure is particularly damaging to cells of the hematopoietic system, inducing pancytopenia and bone marrow failure. The study of these...
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Excitons
In this chapter, we study the Chlorophyll Excitations in the Fenna-Matthews-Olson Complex, we analyze the time dynamics of site probabilities for...
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Isolation of Perivascular Mesenchymal Progenitor Cells from Human Adipose Tissue by Flow Cytometry
Perivascular cells represent an in vivo counterpart of mesenchymal stromal/stem cells that populate the outer layer of blood vessels. Pericytes in...
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Indoles and the advances in their biotechnological production for industrial applications
Indole is a signalling molecule produced both by bacteria and plants. In this review its signalling role between microbes and in particular in the...
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A novel enrofloxacin-degrading fungus, Humicola sp. KC0924g, isolated from the rhizosphere sediment of the submerged macrophyte Vallisneria spiralis L.
A novel enrofloxacin-degrading fungus was isolated from a rhizosphere sediment of the submerged macrophyte Vallisneria spiralis L.. The isolate,...
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Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes
Tetracycline destructases (TDases) are flavin monooxygenases which can confer resistance to all generations of tetracycline antibiotics. The recent...
