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Morphine Induces Differential Gene Expression in Transdifferentiated Neuron-Like Cells from Adipose-Derived Stem Cells
AbstractMorphine is an opiate drug to alleviate pain; however, it has side effects such as tolerance, dependence and addiction. In this study, the in...
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Differential gene expression in Eucalyptus clones in response to nutrient deficiency
We evaluated differential expression of genes in leaf and xylem tissues for three Eucalyptus clones in the field using Illumina sequencing, under...
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Benchmarking causal reasoning algorithms for gene expression-based compound mechanism of action analysis
BackgroundElucidating compound mechanism of action (MoA) is beneficial to drug discovery, but in practice often represents a significant challenge....
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nf-core/circrna: a portable workflow for the quantification, miRNA target prediction and differential expression analysis of circular RNAs
BackgroundCircular RNAs (circRNAs) are a class of covalenty closed non-coding RNAs that have garnered increased attention from the research community...
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Single-cell gene and isoform expression analysis reveals signatures of ageing in haematopoietic stem and progenitor cells
Single-cell approaches have revealed that the haematopoietic hierarchy is a continuum of differentiation, from stem cell to committed progenitor,...
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Omic horizon expression: a database of gene expression based on RNA sequencing data
BackgroundGene expression profiles have important significance for gene expression characteristics and further functional studies. More attention has...
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Genome-wide identification, characterization, and expression analysis of the MAPK gene family in Nardostachys jatamansi (D. Don) DC
Mitogen-activated protein kinase ( MAPK ) cascade is a widely distributed signaling pathway, which is involved in growth, development, and stress...
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Analysis of the Differential Expression and Antiviral Activity of Porcine Interferon-α In Vitro
Porcine interferon α (poIFN-α) is a crucial cytokine that can prevent and treat viral infections. Seventeen functional porcine IFN-α subtypes were...
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IDEAS: individual level differential expression analysis for single-cell RNA-seq data
We consider an increasingly popular study design where single-cell RNA-seq data are collected from multiple individuals and the question of interest...
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Single-nucleus gene and gene set expression-based similarity network fusion identifies autism molecular subtypes
BackgroundAutism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is highly phenotypically and genetically heterogeneous. With...
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Weak gene–gene interaction facilitates the evolution of gene expression plasticity
BackgroundIndividual organisms may exhibit phenotypic plasticity when they acclimate to different conditions. Such plastic responses may facilitate...
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Cloning, tissue expression and imprinting status analysis of the NDN gene in Dolang sheep
BackgroundGenomic imprinting refers to expressing parent-specific genes in mammalian diploid cells. The NDN gene is maternally imprinted in humans...
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Genome-wide identification and expression analysis of the SET domain-containing gene family in potato (Solanum tuberosum L.)
Genes containing the SET domain can catalyse histone lysine methylation, which in turn has the potential to cause changes to chromatin structure and...
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Patch-seq: Multimodal Profiling of Single-Cell Morphology, Electrophysiology, and Gene Expression
Cells exhibit diverse morphologic phenotypes, biophysical and functional properties, and gene expression patterns. Understanding how these features...
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Differential Expression of MicroRNAs in the Kidneys of Rats Following Sustained Swimming Exercise
AbstractSwimming exercise is reported to have protective effects on kidney function. Previous studies have indicated that microRNAs (miRNAs) are...
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PAUSE: principled feature attribution for unsupervised gene expression analysis
As interest in using unsupervised deep learning models to analyze gene expression data has grown, an increasing number of methods have been developed...
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Differential gene expression in a subpopulation of Phaeodactylum tricornutum with enhanced growth and carotenoid production after FACS-mediated selection
Fluorescence-Activated Cell Sorting (FACS) is a powerful method with many applications in microalgal research, especially for screening and selection...
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Colorectal cancer subtype identification from differential gene expression levels using minimalist deep learning
BackgroundCancer molecular subty** plays a critical role in individualized patient treatment. In previous studies, high-throughput gene expression...
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Full-length transcriptome analysis of Ophioglossum vulgatum: effects of experimentally identified chloroplast gene clusters on expression and evolutionary patterns
Genes with similar or related functions in chloroplasts are often arranged in close proximity, forming clusters on chromosomes. These clusters are...
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Weighted gene co-expression network analysis combined with machine learning validation to identify key hub biomarkers in colorectal cancer
Colorectal cancer (CRC) is one of the most common malignancies worldwide; however, the potentially possible molecular biological mechanism of CRC is...
