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Therapeutic Effectiveness of Anticancer Agents Targeting Different Signaling Molecules Involved in Asymmetric Division of Cancer Stem Cell
Intra-tumoral heterogeneity is maintained by cancer stem cells (CSCs) with dysregulated self-renewal and asymmetric cell division (ACD). According to...
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Magnesium Ions Promote In Vitro Rat Bone Marrow Stromal Cell Angiogenesis Through Notch Signaling
Bone defects are often caused by trauma or surgery and can lead to delayed healing or even bone nonunion, thereby resulting in impaired function of...
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Emodin derivatives as promising multi-aspect intervention agents for amyloid aggregation: molecular docking/dynamics simulation, bioactivities evaluation, and cytoprotection
Alzheimer's disease (AD) is a progressive neurodegenerative disease with complex pathogenesis. Despite the pathogenesis is unknown, the misfolding...
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Aβ1−42 stimulates an increase in autophagic activity through tunicamycin-induced endoplasmic reticulum stress in HTR-8/SVneo cells and late-onset pre-eclampsia
Environmental changes can trigger endoplasmic reticulum (ER) stress and misfolded protein accumulation, potentially leading to pre-eclampsia (PE)....
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Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling
Autophagy impairment is commonly implicated in the pathological characteristic of Alzheimer’s disease (AD). Presenilin 1 (PS1) expression in human...
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Signaling Pathways Regulating Cartilage Formation
Over the course of many years of investigation, the molecular processes that regulate the differentiation of chondrocytes throughout the development...
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Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding
Alzheimer’s Disease (AD) is the sixth-leading cause of death in industrialized countries. Neurotoxic amyloid-β (Aβ) plaques are one of the...
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Mechanisms associated with the dysregulation of mitochondrial function due to lead exposure and possible implications on the development of Alzheimer’s disease
Lead (Pb) is a multimedia contaminant with various pathophysiological consequences, including cognitive decline and neural abnormalities. Recent...
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LY450139 Inhibited Ti-Particle-Induced Bone Dissolution via Suppressing Notch and NF-κB Signaling Pathways
Aseptic loosening of the prosthesis caused by wear-particle-induced osteolysis is a long-term complication and one of the most common reasons for the...
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CD44: Does CD44v6 Adversely Impact the Prognosis of Cancer Patients?
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the USA. This high level of CRC death is primarily due to...
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Protein degradation-associated mechanisms that are affected in Alzheimer´s disease
Alzheimer’s disease (AD) is the most common type of dementia associated with age-related neurodegeneration. Alteration of several molecular...
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Pre-clinical evaluation of 99mTc-labeled chalcone derivative for amyloid-β imaging post-head trauma
Aβ 42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most...
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Omics-based biomarkers discovery for Alzheimer's disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorders presenting with the pathological hallmarks of amyloid plaques and tau...
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Mitochondrial disorders leading to Alzheimer’s disease—perspectives of diagnosis and treatment
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia globally. The pathogenesis of AD remains still...
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Mammalian NOTCH Receptor Activation and Signaling Protocols
The NOTCH signaling pathway is one of the highly conserved key pathways involved in most cell differentiation and proliferation processes during both...
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Crystal Structures of Plk1 Polo-Box Domain Bound to the Human Papillomavirus Minor Capsid Protein L2-Derived Peptide
Human papillomaviruses (HPVs) can increase the proliferation of infected cells during HPV-driven abnormalities, such as cervical cancer or benign...
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Finding New Ways How to Control BACE1
Recently, all applications of BACE1 inhibitors failed as therapeutical targets for Alzheimer´s disease (AD) due to severe side effects. Therefore,...
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Physiological functions of SPP/SPPL intramembrane proteases
Intramembrane proteolysis describes the cleavage of substrate proteins within their hydrophobic transmembrane segments. Several families of...
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Identification and characterization of bioactive peptides from marine crustacean crabs: a possible drug candidate for Alzheimer’s disease
Peptide-based drugs have become the most promising drug therapy in the pharmaceutical industry. It accommodates a major part in treating diseases...
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Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
Aging happens to all of us as we live. Thanks to the improved living standard and discovery of life-saving medicines, our life expectancy has...
