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From the regulatory mechanism of TFEB to its therapeutic implications
Transcription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by...
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Identification and validation of seed dormancy loci and candidate genes and construction of regulatory networks by WGCNA in maize introgression lines
Key messageSeventeen PHS-QTLs and candidate genes were obtained, including eleven major loci, three under multiple environments and two with...
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Cumulative effects of weakly repressive regulatory regions in the 3’ UTR maintain PD-1 expression homeostasis in mammals
PD-1 has become a common target for cancer treatment. However, the molecular regulation of PD-1 expression homeostasis remains unclear. Here we...
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Ascorbate oxidases in bread wheat: gene regulatory network, transcripts profiling, and interaction analyses provide insight into their role in plant development and stress response
Ascorbate oxidases (AAOs) are apoplastic enzymes of the multi-copper oxidase family and have a significant role in redox homeostasis. Herein, we...
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Genome-wide expression QTL map** reveals the highly dynamic regulatory landscape of a major wheat pathogen
BackgroundIn agricultural ecosystems, outbreaks of diseases are frequent and pose a significant threat to food security. A successful pathogen...
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SR proteins in cancer: function, regulation, and small inhibitor
Alternative splicing of pre-mRNAs is a fundamental step in RNA processing required for gene expression in most metazoans. Serine and arginine-rich...
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Seed-Based Production of Recombinant Proteins
The use of plants to produce recombinant proteins has become a promising alternative to current expression systems based on microorganisms and cell...
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Transcriptional Regulatory Network Involved in Drought and Salt Stress Response in Rice
Transcription factors (TFs) family intimately regulate gene expression in response to hormones, biotic and abiotic factors, symbiotic interactions,...
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Auxin Transport and Recycling of PIN Proteins in Plants
Polar transport of the phytohormone auxin is mediated by plasma-membrane and endosome localized carrier proteins. PIN proteins are the best...
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PRC1 suppresses a female gene regulatory network to ensure testicular differentiation
Gonadal sex determination and differentiation are controlled by somatic support cells of testes (Sertoli cells) and ovaries (granulosa cells). In...
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Species-aware DNA language models capture regulatory elements and their evolution
BackgroundThe rise of large-scale multi-species genome sequencing projects promises to shed new light on how genomes encode gene regulatory...
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Emerging roles for the ADAMTS-like family of matricellular proteins in cardiovascular disease through regulation of the extracellular microenvironment
Dysregulation of the extracellular matrix (ECM) occurs widely across cardiovascular pathologies. Recent work has revealed important roles for the «a...
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Genome-Wide Profiling of Cis-regulatory Elements in Mammalian Skin
The modulation of cis-regulatory elements (e.g., enhancers and promoters) is a major mechanism by which gene expression can be controlled in a...
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Development of dual reporter vector system for estimating translational activity of regulatory elements
BackgroundFor the needs of modern biotechnology, a quantitative approach to the control of regulatory elements at all stages of gene expression has...
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Transcriptome-wide identification and characterization of the regulatory landscape of NAC genes in Drimia indica
This study was aimed at understanding the role of the NAC transcription factor (TF) gene family in the development and stress responses of Drimia...
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Distinct regulatory networks control toxin gene expression in elapid and viperid snakes
BackgroundVenom systems are ideal models to study genetic regulatory mechanisms that underpin evolutionary novelty. Snake venom glands are thought to...
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Unexpected regulatory functions of cyprinid Viperin on inflammation and metabolism
BackgroundViperin, also known as radical S-adenosyl-methionine domain containing protein 2 (RSAD2), is an interferon-inducible protein that is...
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Study of FOXO1-interacting proteins using TurboID-based proximity labeling technology
BackgroundProtein‒protein interactions (PPIs) are the foundation of the life activities of cells. TurboID is a biotin ligase with higher catalytic...
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Evolution of a plant growth-regulatory protein interaction specificity
Specific protein–protein interactions (PPIs) enable biological regulation. However, the evolution of PPI specificity is little understood. Here we...
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Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer
RNA-binding proteins (RBPs) are key players of gene expression and perturbations of RBP-RNA regulatory network have been observed in various cancer...
