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Reversing the Aged Immune System with Stem Cells
The growing application for stem cells in medicine brings up the question of their role in aging and, to answer, how the information can be used to...
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Participation of Mesenchymal Stem Cells in the Tumor Process
Although most mesenchymal stem cell (MSCs) studies have focused on evaluating the safety and efficacy of their use as therapeutic agents in...
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Trichodermosis: Human Infections Caused by Trichoderma Species
The spectrum of filamentous fungi emerging as opportunistic human pathogens is widening constantly. Various types of mycoses with often severe,...
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PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα
Acute promyelocytic leukemia (APL) is a hematological malignancy driven by the oncoprotein PML-RARα, which can be treated with arsenic trioxide (As 2 O 3 ...
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Assessing the Effect of Histone Deacetylase Inhibitors on DNA Double-Strand Break Repair by Nonhomologous End Joining
This book chapter describes a plasmid-based reporter method, first described by Bennardo et al. (2008) that we use in our laboratory for determining...
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Applications of Peptide Microarrays in Autoantibody, Infection, and Cancer Detection
The diversity of the antigen-specific humoral immune response reflects the interaction of the immune system with pathogens and autoantigens. Peptide...
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The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations
We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-associated genes, complete genomes and transcriptomes for 300...
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Monoclonal Antibodies in Oncology: A Decade of Novel Options
Several decades of research and clinical trials have conclusively provided proof of concept on the usefulness of monoclonal antibodies in the...
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Repurposing FDA approved drugs against monkeypox virus DNA dependent RNA polymerase: virtual screening, normal mode analysis and molecular dynamics simulation studies
Zoonotic monkeypox disease, caused by the double-stranded DNA monkeypox virus, has become a global concern. Due to the absence of a specific small...
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Genome Editing for Engineering the Next Generation of Advanced Immune Cell Therapies
Our current genetic engineering capacity through synthetic biology and genome editing is the foundation of a revolution in biomedical science: the...
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Participation of Mesenchymal Stem Cells in the Tumor Process
Although most mesenchymal stem cell (MSCs) studies have focused on evaluating the safety and efficacy of their use as therapeutic agents in...
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CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis
CCN2, formerly termed Connective Tissue Growth Factor, is a protein belonging to the Cellular Communication Network (CCN)-family of secreted...
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Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and Beyond
Eosinophils are a subset of differentiated granulocytes which circulate in peripheral blood and home in several body tissues. Along with their...
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Effective virus-specific T-cell therapy for high-risk SARS-CoV-2 infections in hematopoietic stem cell transplant recipients: initial case studies and literature review
The COVID-19 pandemic has exacerbated mortality rates among immunocompromised patients, accentuating the need for novel, targeted therapies....
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Neighborhood based computational approaches for the prediction of lncRNA-disease associations
MotivationLong non-coding RNAs (lncRNAs) are a class of molecules involved in important biological processes. Extensive efforts have been provided to...
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The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease
Histone methyltransferase SETDB1 (SET domain bifurcated histone lysine methyltransferase 1, also known as ESET or KMT1E) is known to be involved in...
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Recent advances in lentiviral vectors for gene therapy
Lentiviral vectors (LVs), derived from human immunodeficiency virus, are powerful tools for modifying the genes of eukaryotic cells such as...
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A predictive model combining clinical characteristics and nutritional risk factors for overall survival after umbilical cord blood transplantation
BackgroundUmbilical cord blood transplantation (UCBT) is a curable therapy for hematological disease; however, the impact of nutritional status on...
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Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis
Inflammatory responses rapidly detect pathogen invasion and mount a regulated reaction. However, dysregulated anti-pathogen immune responses can...
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Chromatin structure in cancer
In the past decade, we have seen the emergence of sequence-based methods to understand chromosome organization. With the confluence of in situ ...
