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Incorporating kernelized multi-omics data improves the accuracy of genomic prediction
BackgroundGenomic selection (GS) has revolutionized animal and plant breeding after the first implementation via early selection before measuring...
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Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency
Methylmalonic aciduria (MMA) is an inborn error of metabolism with multiple monogenic causes and a poorly understood pathogenesis, leading to the...
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Multi-omics assisted breeding for biotic stress resistance in soybean
Biotic stress is a critical factor limiting soybean growth and development. Soybean responses to biotic stresses such as insects, nematodes, fungal,...
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Multi-omics reveals new links between Fructosamine-3-Kinase (FN3K) and core metabolic pathways
Fructosamine-3-kinases (FN3Ks) are a conserved family of repair enzymes that phosphorylate reactive sugars attached to lysine residues in peptides...
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Multiview clustering of multi-omics data integration by using a penalty model
BackgroundMethods for the multiview clustering and integration of multi-omics data have been developed recently to solve problems caused by data...
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A benchmark study of deep learning-based multi-omics data fusion methods for cancer
BackgroundA fused method using a combination of multi-omics data enables a comprehensive study of complex biological processes and highlights the...
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Current and future perspectives of single-cell multi-omics technologies in cardiovascular research
Single-cell technology has become an indispensable tool in cardiovascular research since its first introduction in 2009. Here, we highlight the...
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Multimodal Methods for Knowledge Discovery from Bulk and Single-Cell Multi-Omics Data
Multi-omics measurements (bulk and single-cell) are essential to depict the cellular states comprehensively and thus could derive a deep...
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Single-cell multi-omics integration for unpaired data by a siamese network with graph-based contrastive loss
BackgroundSingle-cell omics technology is rapidly develo** to measure the epigenome, genome, and transcriptome across a range of cell types....
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Deciphering the recent trends in pesticide bioremediation using genome editing and multi-omics approaches: a review
Pesticide pollution in recent times has emerged as a grave environmental problem contaminating both aquatic and terrestrial ecosystems owing to their...
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TCGAplot: an R package for integrative pan-cancer analysis and visualization of TCGA multi-omics data
BackgroundPan-cancer analysis examines both the commonalities and heterogeneity among genomic and cellular alterations across numerous types of...
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Single-cell multi-omics analysis of lineage development and spatial organization in the human fetal cerebellum
Human cerebellum encompasses numerous neurons, exhibiting a distinct developmental paradigm from cerebrum. Here we conducted scRNA-seq, scATAC-seq...
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Genetic architecture of inter-specific and -generic grass hybrids by network analysis on multi-omics data
BackgroundUnderstanding the mechanisms underlining forage production and its biomass nutritive quality at the omics level is crucial for boosting the...
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BGFD: an integrated multi-omics database of barley gene families
BackgroundA gene family comprises a group of genes with similar functional domains that play various roles in plant growth, development, and...
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The pear genomics database (PGDB): a comprehensive multi-omics research platform for Pyrus spp.
BackgroundPears are among the most important temperate fruit trees in the world, with significant research efforts increasing over the last years....
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Multi-omics single-cell data integration and regulatory inference with graph-linked embedding
Despite the emergence of experimental methods for simultaneous measurement of multiple omics modalities in single cells, most single-cell datasets...
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Multi-omics Resources for Understanding Gene Regulation in Response to ER Stress in Plants
Proteotoxic stress of the endoplasmic reticulum (ER) is a potentially lethal condition that ensues when the biosynthetic capacity of the ER is...
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Age-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
The incidence of intestinal diseases increases with age, yet the mechanisms governing gut aging and its link to diseases, such as colorectal cancer...
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MDSi: Multi-omics Database for Setaria italica
BackgroundFoxtail millet ( Setaria italica ) harbors the small diploid genome (~ 450 Mb) and shows the high inbreeding rate and close relationship to...
