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Saccharomyces cerevisiae RNA lariat debranching enzyme, Dbr1p, is required for completion of reverse transcription by the retrovirus-like element Ty1 and cleaves branched Ty1 RNAs
RNA debranching enzymes are 2′-5′ phosphodiesterases found in all eukaryotes. Their main role is cleavage of intron RNA lariat branch points,...
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Detection of Intracellular Reactive Oxidative Species Using the Fluorescent Probe Hydroxyphenyl Fluorescein
Various fluorescent probes for the detection of intracellular reactive oxidative species (ROS) have been developed because ROS levels are closely...
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Population Genetic Relationships between Mouflon and Domesticated Sheep Breeds in Highly Polymorphic Genomic Elements
AbstractA comparative analysis of population-genetic structures of three indigenous sheep breeds (Kalmyk, Edilbay, and Karachay breeds) and closely...
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BreakAlign: a Perl program to align chimaeric (split) genomic NGS reads and allow visual confirmation of novel retroviral integrations
BackgroundRetroviruses replicate by integrating a DNA copy into a host chromosome. Detecting novel retroviral integrations (ones not in the reference...
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Proteome-scale tagging and functional screening in mammalian cells by ORFtag
The systematic determination of protein function is a key goal of modern biology, but remains challenging with current approaches. Here we present...
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Origins and evolutionary consequences of ancient endogenous retroviruses
Retroviruses infect a broad range of vertebrate hosts that includes amphibians, reptiles, fish, birds and mammals. In addition, a typical vertebrate...
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Expression of human endogenous retroviruses in pemphigus vulgaris patients
Pemphigus is a severe, potentially life-threatening autoimmune blistering mucocutaneous disease which establishes with autoreactive IgG antibodies...
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The Contribution of Viruses to Immune Systems
Cellular organisms have evolved a plethora of immune systems to defend against selfish genetic elements and pathogens, including viruses....
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Direct Reprogramming Strategies for the Treatment of Nervous System Injuries and Neurodegenerative Disorders
Cell transplantation is an attractive therapeutic avenue for injuries of the central nervous system (CNS) and neurodegenerative disorders....
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Mechanisms of Cell Fusion in Cancer
Cell–cell fusion is a normal physiological mechanism that requires a well-orchestrated regulation of intracellular and extracellular factors....
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Direct Reprogramming Strategies for the Treatment of Nervous System Injuries and Neurodegenerative Disorders
Cell transplantation is an attractive therapeutic avenue for injuries of the central nervous system (CNS) and neurodegenerative disorders....
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Frequent retrotransposition of endogenous genes in ERCC2-deficient cells derived from a patient with xeroderma pigmentosum
BackgroundRetrotransposition of protein-coding genes is thought to occur due to the existence of numerous processed pseudogenes in both animals and...
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PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads
The integration of a viral genome into the host genome has a major impact on the trajectory of the infected cell. Integration location and variation...
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Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2
Brain development and function require uptake of essential omega-3 fatty acids in the form of lysophosphatidylcholine via major-facilitator...
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LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells
LIN28 is an RNA binding protein with important roles in early embryo development, stem cell differentiation/reprogramming, tumorigenesis and...
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Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice
Centromere identity is defined by nucleosomes containing CENP-A, a histone H3 variant. The deposition of CENP-A at centromeres is tightly regulated...
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T-cell receptor gene therapy targeting melanoma-associated antigen-A4 by silencing of endogenous TCR inhibits tumor growth in mice and human
Genetically engineered T cells expressing a T-cell receptor (TCR) are powerful tools for cancer treatment and have shown significant clinical effects...
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Transcriptional dynamics of transposable elements when converting fibroblast cells of Macaca mulatta to neuroepithelial stem cells
BackgroundTransposable elements (TE) account for more than 50% of human genome. It has been reported that some types of TEs are dynamically regulated...
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Development of Cas13a-based therapy for cancer treatment
Gene therapy has become a major focus of current biomedical research. CRISPR (Clustered Regularly Inter spaced Short Palindromic Repeats) systems...
