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Genetics of atrial fibrillation—an update of recent findings
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. AF has a strong...
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The Role of Mechanosensitive Signaling Cascades in Repair and Fibrotic Remodeling of the Infarcted Heart
The adult mammalian heart has negligible regenerative capacity and heals through formation of a collagen-based scar. Repair of the infarcted heart...
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Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads
Here we show that striated muscle preferentially expressed protein kinase α (Spegα) maintains cardiac function in hearts with Spegβ deficiency. Speg...
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Spermidine, an Autophagy Inducer, as a Therapeutic Antiaging Strategy
Aging is an ineluctable physiological process that occurs in humans and is often known to progress towards death. It is associated with organ...
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Induced Pluripotent Stem Cells and Allogeneic Mesenchymal Stem Cell Therapy in Cardiovascular Diseases
Cell- and gene-based therapies form one of the pillars of regenerative medicine. This chapter reviews the recent progress in applying advanced...
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A guide for assessment of myocardial stiffness in health and disease
Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic and systolic cardiac function. Myocardial stiffness...
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Passive myocardial mechanical properties: meaning, measurement, models
Passive mechanical tissue properties are major determinants of myocardial contraction and relaxation and, thus, shape cardiac function. Tightly...
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A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C
Familial cardiomyopathy is an inherited disease that affects the structure and function of heart muscle and has an extreme range of phenotypes. Among...
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Mechanosignaling pathways alter muscle structure and function by post-translational modification of existing sarcomeric proteins to optimize energy usage
A transduced mechanical signal arriving at its destination in muscle alters sarcomeric structure and function. A major question addressed is how...
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Arrhythmogenic Cardiomyopathy: from Preclinical Models to Genotype–phenotype Correlation and Pathophysiology
Arrhythmogenic cardiomyopathy (ACM) is a hereditary myocardial disease characterized by the replacement of the ventricular myocardium with fibrous...
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Cardiomyocyte-specific disruption of the circadian BMAL1–REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart
Circadian disruption increases cardiovascular disease (CVD) risk, through poorly understood mechanisms. Given that small RNA species are critical...
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Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway
Cardiac fibroblast (CF) differentiation into myofibroblasts is a crucial cause of cardiac fibrosis, which increases in the extracellular matrix (ECM)...
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RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathy
The IGF2BP family of RNA binding proteins consists of three paralogs that regulate intracellular RNA localization, RNA stability, and translational...
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Cardiac Immunology: A New Era for Immune Cells in the Heart
The immune system is essential for the development and homeostasis of the human body. Our current understanding of the immune system on disease...
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Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) hold great potential in the cardiovascular field for human disease modeling,...
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Circular RNAs: a small piece in the heart failure puzzle
Cardiovascular disease, specifically heart failure (HF), remains a significant concern in the realm of healthcare, necessitating the development of...
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Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes
BackgroundNeurovascular cells have wide-ranging implications on skeletal muscle biology regulating myogenesis, maturation, and regeneration. Although...
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Mechanosensory Structures in the Mechanotransduction System of Muscle Fibers
AbstractThe ability of skeletal muscles to sense mechanical stimuli and respond to them by changing intracellular electrochemical and biochemical...
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Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure
In striated muscle, the sarcomeric protein myosin-binding protein-C (MyBP-C) is bound to the myosin thick filament and is predicted to stabilize...
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Response of Cardiomyocytes to Mechanical Stress
Mechanical stretch activates several intracellular signalling networks and modulates gene expressions which initiate structural and functional...