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Response of Cardiomyocytes to Mechanical Stress

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Cardiomyocytes in Health and Disease

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Abstract

Mechanical stretch activates several intracellular signalling networks and modulates gene expressions which initiate structural and functional remodelling in cardiomyocytes. Various durations, loads and frequencies of mechanical forces induce differing response mechanisms. Cardiomyocytes remodel in response to mechanical stress both during cardiac development as well as in disease conditions. In both of these situations, the cytoskeleton has a key role in sensing mechanical stress and in mediating adaptive or maladaptive changes within the cardiomyocyte. Cytoskeleton which is highly sensitive and adaptive to mechanical forces acts as a signal integrator for mechanical and structural inputs. The information is transmitted throughout the cardiomyocyte to ensure that the cell respond and adapt appropriately. Mechanical stretch induces secretion or synthesis of molecules with autocrine and paracrine effects. Energy metabolism is also altered in adult cardiomyocytes, which hypertrophy in response to mechanical stress.

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    Chandrasekharan C. Kartha

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Kartha, C.C. (2021). Response of Cardiomyocytes to Mechanical Stress. In: Cardiomyocytes in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-85536-9_8

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