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Bacillus Swezeyi B2 Strain: A Novel Alkaliphilic Bacterium Producer of Alkaline-, Thermal, Oxidant-, and Surfactant-Stable Protease, Extremely Efficient in Detergency
Proteolytic enzymes that are currently used to meet industrial demand are usually derived from Bacillus species. They find multiple technical...
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Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner
Posttranslational modifications add tremendous complexity to proteomes; however, gaps remain in knowledge regarding the function and regulatory...
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Staphylococcus aureus foldase PrsA contributes to the folding and secretion of protein A
BackgroundStaphylococcus aureus secretes a variety of proteins including virulence factors that cause diseases. PrsA, encoded by many Gram-positive...
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mTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA
Osteosarcoma (OS) is considered a sex steroid hormone-dependent bone tumor. The development and progression of OS are regulated by 17β-estradiol...
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Neuronal MHC-I complex is destabilized by amyloid-β and its implications in Alzheimer’s disease
BackgroundsThe expression of major histocompatibility complex I (MHC-I) in neurons has recently been shown to regulate neurite outgrowth and synaptic...
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Plant-Based Antibody Manufacturing
Plant-based manufacture of antibodies and other biologics is a rapidly growing area of interest to the biopharmaceutical industry. The use of plants...
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Differential analysis of core-fucosylated glycoproteomics enabled by single-step truncation of N-glycans
Alpha-1,6 fucosylation of N -glycans (core fucosylation, CF) represents a unique form of N -glycans and is widely involved in disease progression. In...
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Comprehensive multi-attribute method workflow for biotherapeutic characterization and current good manufacturing practices testing
The multi-attribute method (MAM) is a liquid chromatography-mass spectrometry (LC-MS)-based method that is used to directly characterize and monitor...
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Identifying Cyclin A/Cdk1 Substrates in Mitosis in Human Cells
Cyclin A promotes Cdk activity in a cell cycle-dependent manner to facilitate specific cell cycle events and transitions with an established role for...
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Novel helix loop-mediated isothermal amplification (HAMP) assay for colorimetric detection of Staphylococcus aureus in milk
Staphylococcus aureus is an important and leading cause of foodborne diseases worldwide. Prompt detection and recall of contaminated foods are...
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Purification and characterization of L-Amino acid oxidase from Aspergillus terreus MZ769058
L-Amino acid oxidase has significant values in different biotechnology sectors. In this study, Aspergillus terreus MZ769058 was reported as new...
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Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function
Activation of receptor protein kinases is prevalent in various cancers with unknown impact on ferroptosis. Here we demonstrated that AKT activated by...
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Use of Trehalose as an Additive to Bacteriophage Vb_Pd_PDCC-1: Long-Term Preservation Analysis and Its Biocontrol Against Vibrio diabolicus Infection
Phage therapy is a promising alternative to control bacterial diseases and the increasing problem of antibiotic resistance. In this sense, this...
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Development of ULYSSIS, a Tool for the Biosynthesis of Cyclotides and Cyclic Knottins
Many human disorders and discomforts can potentially be treated by peptide-based medicines. There are two major problems in using peptide-based...
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Highly sensitive therapeutic drug monitoring of infliximab in serum by targeted mass spectrometry in comparison to ELISA data
BackgroundPresently, antibody concentration measurements for patients undergoing treatment are predominantly determined by ELISA, which still comes...
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Homoscleromorpha-derived Bacillus spp. as potential sources of biotechnologically-relevant hydrolases and biosurfactants
Despite hydrolytic exoenzymes and biosurfactants having been gradually reported from the poriferan microbiome, little is known about these...
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Oligoagars and microbial agents show potential for Porphyra disease prevention
Disease is a major concern in Porphyra aquaculture, particularly during the early shell-borne conchocelis (SBC) seedling stage. To explore prevention...
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Synthesis of Graphene Quantum Dot Magnesium Hydroxide Nanocomposites and Investigation of Their Antioxidant and Antimicrobial Activities
In this paper, we synthesized graphene quantum dots magnesium hydroxide nanocomposites (GQDs/Mg(OH) 2 ). The synthesized nanocomposites were...
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Genetic Markers and Biotechnology
Horsegram is a self-pollinated crop; therefore variation in the DNA polymorphism is not much expected. Limited work has been done on the aspect of...
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Regulation of urea cycle by reversible high-stoichiometry lysine succinylation
The post-translational modification lysine succinylation is implicated in the regulation of various metabolic pathways. However, its biological...
