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Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53
Despite the use of many types of chemotherapies for pancreatic cancer, optimal efficacy has not been obtained so far. Pancreatic cancer shows a high...
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Preparation of Nanosensors for Detecting the Activity of Glycosaminoglycan Cleaving Enzymes
Glycosaminoglycans (GAGs) play crucial roles in several biological processes including cell division, angiogenesis, anticoagulation, neurogenesis,...
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Assembly of Human Papillomavirus 16 L1 Protein in Nicotiana benthamiana Chloroplasts into Highly Immunogenic Virus-Like Particles
Infection with human papillomavirus (HPV) can cause cervical cancers in women, and vaccination against the virus is one of most effective ways to...
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Decellularization, cross-linking and heparin immobilization of porcine carotid arteries for tissue engineering vascular grafts
Tissue engineering vascular grafts (TEVGs) have the potential to replace small-diameter grafts in bypass surgery which is good news for patients with...
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The Effect of Chitosan on Blood Coagulation in Heparinized Rats
AbstractThe chitosan added to heparinized blood plasma in vitro at concentrations of 10 –2 , 10 –1 , 1, 5, and 10 mg/mL dose-dependent reduced...
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Ascidian (Chordata-Tunicata) Glycosaminoglycans: Extraction, Purification, Biochemical, and Spectroscopic Analysis
Sulfate polysaccharides with unique structures of the chondroitin/dermatan and heparin/heparan families of sulfated glycosaminoglycans have been...
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Detection of the residual concentration of sodium dodecyl sulfate in the decellularized whole rabbit kidney extracellular matrix
To optimize rabbit kidney decellularization protocol, using sodium dodecyl sulfate (SDS) as a commonly used detergent, a methylene blue based assay...
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Impact of Chronic Sodium Fluoride Toxicity on Antioxidant Capacity, Biochemical Parameters, and Histomorphology in Cardiac, Hepatic, and Renal Tissues of Wistar Rats
The study was designed to determine the fluoride distribution after its oral exposure in drinking water and its associated impact on biochemical,...
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Humoral immune response induced with dengue virus-like particles serotypes 1 and 4 produced in silkworm
Dengue is an arboviral disease, which threatens almost half the global population, and has emerged as the most significant of current global public...
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Comparative study of hematological parameters of Colossoma macropomum anesthetized with benzocaine and eugenol by using different anticoagulants
The objective of the present study was to evaluate the action of benzocaine and eugenol over anesthesia stages and the use of three anticoagulants...
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Purification and biochemical characterization of extracellular thermostable lipase from Bacillus sp. strain L2
In the current study, an extracellular thermostable lipase from Bacillus sp. strain L2 was produced and purified through two-steps purifications,...
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Nutritional Supplementation and Enhanced Antioxidant Function by Dietary Intake of Selenoneine and Other Selenium Compounds in Red Seabream Pagrus major
Selenoneine, 2-selenyl- N α , N α , N α -trimethyl- L -histidine, is the major organic selenium compound in marine fish. To characterize biological...
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Impact of Ozone on the Oxygen Affinity Blood Properties and Prooxidant-Antioxidant Balance under Effect of H2S-Generating System
AbstractHydrogen sulfide belongs to the group of signaling agents called gaseous transmitters and plays an important role in many physiological...
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Heparanase modulation by Wingless/INT (Wnt)
Heparanase is an endo-beta-glucuronidase, the only enzyme in mammals capable of cleaving heparan sulfate/heparin chains from proteoglycans. The...
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Synergistic Effect of Whitlockite Scaffolds Combined with Alendronate to Promote Bone Regeneration
Background:Due to the increasing aging of society, the number of patients suffering from senile diseases is increasing. Patients suffering from...
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Development of a Platform for Producing Recombinant Protein Components of Epitope Vaccines for the Prevention of COVID-19
AbstractA new platform for creating anti-coronavirus epitope vaccines has been developed. Two loop-like epitopes with lengths of 22 and 42 amino acid...
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Bioengineered production of glycosaminoglycans and their analogues
Glycosaminoglycans (GAGs) are a class of linear polysaccharides, consisting of alternating disaccharide sequences of uronic acid and hexosamines (or...
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Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
BackgroundInterferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells...
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Effect of Parenteral Supplementation of Minerals and Vitamins on Oxidative Stress Biomarkers and Hepatic Fatty Acid Metabolism in Dairy Cows During the Transition Period
In the present work we aimed to study the effects of parenteral vitamin and mineral supplementation on hepatic fatty acid metabolism as well as on...
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Sulfated Derivatives of Arabinogalactan and Their Anticoagulant Activity
AbstractA comparison of IR spectra and molecular weight distribution of arabinogalactan sulfates as sodium and ammonium salts obtained using various...
