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Designing a novel drug–drug conjugate as a prodrug for breast cancer therapy: in silico insights
Breast cancer (BC) poses a significant global health threat, necessitating innovative therapeutic approaches. The ribosomal s6 kinase 2 (RSK2) has...
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Drug Delivery Systems for Tissue Engineering
Drug delivery systemsDrug delivery systems (DDSs) are developed having in view the need to control the dose (within the therapeuticTherapeutic...
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Combination of furosemide, gold, and dopamine as a potential therapy for breast cancer
Breast cancer is one of the leading causes of death in women worldwide. Initially, it develops in the epithelium of the ducts or lobules of the...
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Computer-Aided Drug Design: An Update
Computer-aided drug design (CADD) approaches are playing an increasingly important role in understanding the fundamentals of ligand-receptor...
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High-Throughput Structure-Based Drug Design (HT-SBDD) Using Drug Docking, Fragment Molecular Orbital Calculations, and Molecular Dynamic Techniques
Structure-based drug design (SBDD) is rapidly evolving to be a fundamental tool for faster and more cost-effective methods of lead drug discovery....
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Predicting Drug Synergy and Discovering New Drug Combinations Based on a Graph Autoencoder and Convolutional Neural Network
Drug synergy is a crucial component in drug reuse since it solves the problem of sluggish drug development and the absence of corresponding drugs for...
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The Future of Drug Development with Quantum Computing
Novel medication development is a time-consuming and expensive multistage procedure. Recent technology developments have lowered timeframes,...
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Identification of lipid-modifying drug targets for autoimmune diseases: insights from drug target mendelian randomization
BackgroundsA growing body of evidence has highlighted the interactions of lipids metabolism and immune regulation. Nevertheless, there is still a...
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Synergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer
Colorectal cancer (CRC) is the third most common cancer associated with a poor prognosis. Effective targeted therapy alone or in combination for...
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Novel Targeting Carriers in Antibody-Drug Conjugates
Various targeting carriers are being applied to drug conjugates since the clinical success of antibody-drug conjugate. For example, PDC (peptide-drug...
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Drug Repurposing: An Approach for Reducing Multidrug Resistance
Drug repurposing is paving ways to develop new therapeutic uses of old drugs which can be helpful in treatment of common and rare diseases. Multidrug...
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The potential therapeutic effect of melatonin in oxaliplatin combination therapy against chemoresistant colorectal cancer cells
BackgroundOxaliplatin is one of the main therapeutics in colorectal cancer (CRC) chemotherapy. However, in light of multidrug resistance (MDR)...
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Unveiling the mechanisms and challenges of cancer drug resistance
Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and acquired...
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MCL-DTI: using drug multimodal information and bi-directional cross-attention learning method for predicting drug–target interaction
BackgroundPrediction of drug–target interaction (DTI) is an essential step for drug discovery and drug reposition. Traditional methods are mostly...
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Prediction of Adverse Effects of Drug–Drug Interactions on Cardiovascular System Based on the Analysis of Structure–Activity Relationships
AbstractCo-administration of drugs often leads to drug–drug interactions, which could be accompanied by various adverse drug reactions that pose a...
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A novel doxorubicin/CTLA-4 blocker co-loaded drug delivery system improves efficacy and safety in antitumor therapy
Doxorubicin’s antitumor effectiveness may be constrained with ineffective tumor penetration, systemic adverse effects, as well as drug resistance....
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Multi-view feature representation and fusion for drug-drug interactions prediction
BackgroundDrug-drug interactions (DDIs) prediction is vital for pharmacology and clinical application to avoid adverse drug reactions on patients. It...
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Repression of resistance mechanisms of Pseudomonas aeruginosa: implications of the combination of antibiotics and phytoconstituents
Antimicrobial resistance is a prevalent problem witnessed globally and creating an alarming situation for the treatment of infections caused by...
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VIBRANT: spectral profiling for single-cell drug responses
High-content cell profiling has proven invaluable for single-cell phenoty** in response to chemical perturbations. However, methods with improved...
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Computational Modelling and Simulations in Drug Design
One of the key operations in the pharmaceutical sector is the creation of new drugs. The time and expense associated with drug discovery have been...