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Optimised stacked machine learning algorithms for genomics and genetics disorder detection in the healthcare industry
With recent advances in precision medicine and healthcare computing, there is an enormous demand for develo** machine learning algorithms in...
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Gossypium mustelinum genome and an introgression population enrich interspecific genetics and breeding in cotton
Key messageGenomic and genetic resources of G. mustelinum were effective for identifying genes for qualitative and quantitative traits.
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LncRNAs in neuropsychiatric disorders and computational insights for their prediction
Long non-coding RNAs (lncRNAs) are 200 nucleotide extended transcripts that do not encode proteins or possess limited coding ability. LncRNAs...
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Computational gastronomy: A data science approach to food
Cooking forms the core of our cultural identity other than being the basis of nutrition and health. The increasing availability of culinary data and...
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Genetics Behind Sexual Incompatibility in Plants: How Much We Know and What More to Uncover?
Self-incompatibility (SI) is an adaptive strategy in plants that increase genetic variability by promoting cross-pollination and reducing the chances...
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Whole-Genome Genoty** Using DNA Microarrays for Population Genetics
The field of population genetics has exploded in the last two decades following the sequencing of the human genome in 2001 (Green et al. Nature...
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Landscape genetics identifies barriers to Natterjack toad metapopulation dispersal
Habitat fragmentation and loss reduce population size and connectivity, which imperils populations. Functional connectivity is key for species...
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Small open reading frames: a comparative genetics approach to validation
Open reading frames (ORFs) with fewer than 100 codons are generally not annotated in genomes, although bona fide genes of that size are known. Newer...
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Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease
The human leukocyte antigen (HLA) locus is associated with more complex diseases than any other locus in the human genome. In many diseases, HLA...
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Computational Omics Protocol for the Comparative Study of Microbiome Analysis
Exploring the microbiome involves an integrative approach of metagenomics, metabolomics, metatranscriptomics, and meta-proteomics combined with...
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Glycopeptide Antibiotics: Genetics, Chemistry, and New Screening Approaches
Glycopeptide antibiotics (GPAs) that target bacterial cell wall remain one of the most successful families of antibiotics. GPAs are produced by...
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Systems Approach for Identifying Drug Targets by Computational Approaches
Large datasets are frequently gathered, stored and analysed in the big data age with the goal of guiding biological discoveries and validating...
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Computational Detection of MicroRNA Targets
MicroRNAs (miRNAs) are small noncoding RNAs that are recognized as posttranscriptional regulators of gene expression. These molecules have been shown...
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COMPILE: a GWAS computational pipeline for gene discovery in complex genomes
BackgroundGenome-Wide Association Studies (GWAS) are used to identify genes and alleles that contribute to quantitative traits in large and...
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Large-scale analysis of sheep rumen metagenome profiles captured by reduced representation sequencing reveals individual profiles are influenced by the environment and genetics of the host
BackgroundProducing animal protein while reducing the animal’s impact on the environment, e.g., through improved feed efficiency and lowered methane...
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Computational dissection of genetic variation modulating the response of multiple photosynthetic phenotypes to the light environment
BackgroundThe expression of biological traits is modulated by genetics as well as the environment, and the level of influence exerted by the latter...
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Computational Evolutionary Biology
Evolution is the dynamic process where a species or population undergo change in heritable characteristics. The study of evolution is called...
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Computational design of PD-L1 small molecule inhibitors for cancer therapy
Drug repurposing opens new avenues in cancer therapy. Drug repurposing, or finding new uses for existing drugs, can substantially reduce drug...
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35th International Mammalian Genome Conference: meeting overview
The 35th International Mammalian Genome Conference (IMGC) was held on July 17–20, 2022 in Vancouver, British Columbia; this conference marked the...