Abstract
Glycopeptide antibiotics (GPAs) that target bacterial cell wall remain one of the most successful families of antibiotics. GPAs are produced by Actinobacteria, a class of Gram-positive microorganisms with complex life cycle and sizable genomes. The elucidation of biosynthesis of GPAs is important for several reasons. First, GPA producers are likely a primary source of respective antimicrobial resistance (AMR) genes; their study will inform us of possible ways for AMR evolution among pathogens. Second, the biosynthetic studies yield information about regulatory mechanisms governing the production of GPAs, which can be used in biotechnology. Third, manipulation of GPA biosynthetic genes is a viable approach to generate novel GPAs of practical value. Lastly, the information on GPA genes can be used to find new compounds through computational analyses of publicly available genomic information. In this chapter, we outline a comprehensive picture of GPAs, focusing on genetics and chemistry behind their biosynthetic pathways. Examples of the use of the gained knowledge for strain improvement and discovery of novel compounds are given. A concise outlook of bioactivities exhibited by GPAs will conclude the chapter.
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Yushchuk, O., Ostash, B. (2022). Glycopeptide Antibiotics: Genetics, Chemistry, and New Screening Approaches. In: Rai, R.V., Bai, J.A. (eds) Natural Products from Actinomycetes. Springer, Singapore. https://doi.org/10.1007/978-981-16-6132-7_16
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