Search
Search Results
-
Multiplexed Phagosomal Assays for the Detection and Quantification of Bidirectional Exchange Between the Phagolysosomal Lumen and Extracellular Space
The phagolysosome is an antimicrobial and degradative organelle that plays a key role in macrophage-mediated inflammation and homeostasis. Before...
-
Isolation of Polystyrene Bead-Induced Phagosomes for Western Blotting
The engulfment of “self” and “non-self” particles by immune and non-immune cells is crucial for maintaining homeostasis and combatting infection....
-
Sec22b regulates phagosome maturation by promoting ORP8-mediated lipid exchange at endoplasmic reticulum-phagosome contact sites
Phagosome maturation is critical for immune defense, defining whether ingested material is destroyed or converted into antigens. Sec22b regulates...
-
Quantifying Phagocytosis by Immunofluorescence and Microscopy
Phagocytosis is carried out by cells such as macrophages of the immune system, whereby particulates like bacteria and apoptotic bodies are engulfed...
-
epHero – a tandem-fluorescent probe to track the fate of apoptotic cells during efferocytosis
The efficient removal of apoptotic cells via efferocytosis is critical for maintaining optimal tissue function. This involves the binding and...
-
Host Lipid Manipulation by Intracellular Bacteria: Moonlighting for Immune Evasion
Lipids are complex organic molecules that fulfill energy demands and sometimes act as signaling molecules. They are mostly found in membranes, thus...
-
p40phox: Composition, Function and Consequences of Its Absence
The NOX2 protein complex in human leukocytes consists of five proteins: gp91phox (NOX2) and p22phox (together called flavocytochrome b558) embedded...
-
-
The Role of Rab GTPases in the development of genetic and malignant diseases
Small GTPases have been shown to play an important role in several cellular functions, including cytoskeletal remodeling, cell polarity,...
-
Transcriptome analysis of the immunoprotective effect of Bacillus licheniformis on the intestinal tract of Carassius auratus gibelio infected with Aeromonas hydrophila
Carassius auratus gibelio, commonly known as crucian carp, is the main species of freshwater aquaculture in China. Due to high-density aquaculture...
-
Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism
Age-related changes in testicular function can impact health and well-being. The mechanisms underlying age-related testicular dysfunction, such as...
-
Intracellular Pathogens: Infection, Immunity, and Intervention
Intracellular pathogens comprise a diverse group of pathogens that all share a required location in a host cell to infect, survive, and replicate....
-
Chronic Granulomatous Disease
Chronic granulomatous disease (CGD) is an immunodeficiency that affects phagocytic leukocytes (neutrophils, monocytes, macrophages and eosinophils)....
-
Effect of diabetes on efferocytosis process
Diabetes is a complex of genetic, metabolic, and autoimmune disorders that are characterized by hyperglycemia. Elevated apoptotic cell count...
-
Apolipoprotein A-I Inhibits Increased Activity of Chitotriosidase and β-Glucosaminidase in the Liver of Mice with BCG-Induced Tuberculous Inflammation
AbstractThe aim of this study was to study the activity of lysosomal chitinases (chitotriosidase and β-glucosaminidase) in the liver of mice on a...
-
Molecular characterization of Rab5A, and involvement in innate immunity in Yellow River Carp Cyprinus carpio
Rab5A play important roles in regulating trafficking organelles, especially in phagosome formation. In the present study, full-length cDNA sequences...
-
Involvement of Cathepsins Protein in Mycobacterial Infection and Its Future Prospect as a Therapeutic Target
Tuberculosis (TB), the second most fatal infectious disease after HIV, is caused by Mycobacterium tuberculosis ( M. tuberculosis or MTB). It is a...
-
Effects and mechanisms of Salmonella plasmid virulence gene spv on host-regulated cell death
Salmonella is responsible for the majority of food poisoning outbreaks around the world. Pathogenic Salmonella mostly carries a virulence plasmid...
-
ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages
Autophagy is a cellular innate-immune defence mechanism against intracellular microorganisms, including Mycobacterium tuberculosis (Mtb). How...
-
Efferocytosis: a double-edged sword in microbial immunity
Efferocytosis is characterized as the rapid and efficient process by which dying or dead cells are removed. This type of clearance is initiated via...
