Search
Search Results
-
High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for OXPHOS complex I, III, and V inhibitors
Cells can adjust their mitochondrial morphology by altering the balance between mitochondrial fission and fusion to adapt to stressful conditions....
-
Functional, structural, and molecular remodelling of the goldfish (Carassius auratus) heart under moderate hypoxia
The goldfish ( Carassius auratus ) is known for its physiologic ability to survive even long periods of oxygen limitation (hypoxia), adapting the...
-
PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration
Neurodegenerative disorders are characterized by the progressive loss of structure and function of neurons, often including the death of the neuron....
-
Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
Meriolin derivatives represent a new class of kinase inhibitors with a pronounced cytotoxic potential. Here, we investigated a newly synthesized...
-
FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control
Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain injury (TBI), which result in...
-
Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy
Mitochondrial dysfunction and mitophagy are often hallmarks of neurodegenerative diseases such as autosomal dominant optic atrophy (ADOA) caused by...
-
Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice
Dietary restriction (DR) is a potential intervention for ameliorating ageing-related damages. Mitochondrial quality control is the key mechanism for...
-
The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism
Inhibition of the mitochondrial metabolism offers a promising therapeutic approach for the treatment of cancer. Here, we identify the mycotoxin...
-
Disturbances in mitochondrial bioenergetics and control quality and unbalanced redox homeostasis in the liver of a mouse model of mucopolysaccharidosis type II
Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a lysosomal storage disease caused by mutations in the gene encoding the enzyme iduronate...
-
Crosstalk Between the Mitochondrial Dynamics and Oxidative Stress in Zinc-induced Cytotoxicity
Zinc is an essential trace element, which plays an important role in multiple biological activities. However, excessive exposure to zinc can cause...
-
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
BackgroundThe mitochondrial gene MCCC2, a subunit of the heterodimer of 3-methylcrotonyl-CoA carboxylase, plays a pivotal role in catabolism of...
-
Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury
Mitochondria take part in a network of intracellular processes that regulate homeostasis. Defects in mitochondrial function are key...
-
Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis
The recruitment of DRP1 to mitochondrial membranes prior to fission is facilitated by the wrap** of endoplasmic reticulum (ER) membranes around the...
-
Atomoxetine Decreases Mitochondrial Biogenesis, Fission and Fusion In Human Neuron-like Cells But Does Not Alter Antioxidant Defences
Atomoxetine (ATX) is a presynaptic norepinephrine transporter (NET) inhibitor widely prescribed for attention-deficit/hyperactivity disorder (ADHD)...
-
Alternaria species causing pomegranate and citrus fruit rots in Albania
The fungal genus Alternaria is a relevant pathogen for several commodities including citrus and pomegranate fruits. On citrus, it mainly causes brown...
-
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response
Mitochondrial dysfunction is becoming one of the main pathology factors involved in the etiology of neurological disorders. Recently, mutations of...
-
Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury
BackgroundCerebral ischemia-reperfusion injury (CIRI) is the main cause leading to high mortality and neurological disability in patients with...
-
ROMO1 is required for mitochondrial metabolism during preimplantation embryo development in pigs
BackgroundReactive oxygen species (ROS) modulator 1 (ROMO1) is a mitochondrial membrane protein that is essential for the regulation of mitochondrial...
-
Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy
Cadmium is one of the environmental and occupational pollutants and its potential adverse effects on human health have given rise to substantial...
