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The possible role of Helicobacter pylori in liver diseases
According to previous studies, Helicobacter pylori infection is associated with liver disease. In order to better understand the risk of acquiring...
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CagL polymorphisms between East Asian and Western Helicobacter pylori are associated with different abilities to induce IL-8 secretion
Helicobacter pylori colonizes human gastric mucosa. Its infection is associated with gastric diseases including gastric cancer. CagA is one of the...
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Unique TLR9 Activation by Helicobacter pylori Depends on the cag T4SS, But Not on VirD2 Relaxases or VirD4 Coupling Proteins
The genomes of the gastric bacterial pathogen Helicobacter pylori harbor multiple type-IV secretion systems (T4SSs). Here we analyzed components of...
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Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran
The purpose of this study was to determine the mutations associated with clarithromycin resistance in Helicobacter pylori strains isolated from...
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Prevalence of cagA, cagM, vacA and oipA genes in isolates of Helicobacter pylori obtained from hospital patients in Northeast Brazil
Helicobacter pylori is a major cause of gastrointestinal disorders such as chronic gastritis, peptic ulcers, mucosa-associated lymphoid tissue (MALT)...
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Exploring virulence factors of Helicobacter pylori isolated from gastric biopsy
BackgroundHelicobacter pylori ( H. pylori ) colonizes human gastric mucosa and is classified as class one carcinogenic bacteria. In this regard, this...
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Genetic variation in the cag pathogenicity island of Helicobacter pylori strains detected from gastroduodenal patients in Thailand
There is a lack of evidence of genetic variation in the Helicobacter pylori cag -PAI in Thailand, a region with the low incidence of gastric cancer....
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Extent of Virulence and Antibiotic Resistance Genes in Helicobacter pylori and Campylobacteria
Helicobacter pylori , a member of the clade campylobacteria, is the leading cause of chronic gastritis and gastric cancer. Virulence and antibiotic...
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Investigation of Clarithromycin Resistance-Associated Mutations and Virulence Genotypes of Helicobacter pylori Isolated from Iranian Population: A Cross-Sectional Study
Antibiotic resistance has brought into question the efficiency of clarithromycin which is a vital component of eradication therapy for Helicobacter...
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Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway
BackgroundMetabolic reprogramming is a critical event for cell fate and function, making it an attractive target for clinical therapy. The function...
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Current research on the interaction between Helicobacter pylori and macrophages
Helicobacter pylori ( H. pylori ) is a gram-negative bacteria with a worldwide infection rate of 50%, known to induce gastritis, ulcers and gastric...
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Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA
Single nucleotide polymorphisms (SNPs) account for significant genomic variability in microbes, including the highly diverse gastric pathogen Helicobac...
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Helicobacter pylori in the post-antibiotics era: from virulence factors to new drug targets and therapeutic agents
Helicobacter pylori is considered one of the most prevalent human pathogenic microbes globally. It is the main cause of a number of gastrointestinal...
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Autophagy induced by Helicobacter Pylori infection can lead to gastric cancer dormancy, metastasis, and recurrence: new insights
According to the findings of recent research, Helicobacter Pylori ( H. pylori ) infection is not only the primary cause of gastric cancer (GC), but it...
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Prevalence of Helicobacter pylori Virulence Genes and Their Association with Chronic Gastritis in Bei**g, China
Helicobacter pylori is closely related to chronic gastritis. The aim of the study was to investigate the correlation between H. pylori virulence...
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Comprehensive insight into altered host cell-signaling cascades upon Helicobacter pylori and Epstein–Barr virus infections in cancer
Cancer is characterized by mutagenic events that lead to disrupted cell signaling and cellular functions. It is one of the leading causes of death...
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Role of Helicobacter pylori virulence factors and alteration of the Tumor Immune Microenvironment: challenges and opportunities for Cancer Immunotherapy
Various forms of malignancies have been linked to Helicobacter pylori . Despite advancements in chemotherapeutic and surgical approaches, the...
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H. pylori infection confers resistance to apoptosis via Brd4-dependent BIRC3 eRNA synthesis
H. pylori infection is one of the leading causes of gastric cancer and the pathogenicity of H. pylori infection is associated with its ability to...
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Helicobacter pylori infection induces abnormal expression of pro-angiogenic gene ANGPT2 and miR-203a in AGS gastric cell line
Helicobacter pylori colonizes the stomach and induces an inflammatory response that can develop into gastric pathologies including cancer. The...
