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Enhanced Natural Killers with CISH and B2M Gene Knockouts Reveal Increased Cytotoxicity in Glioblastoma Primary Cultures
AbstractIn an experimental study using the CRISPR/Cas9 system, “enhanced” NK cell lines with knockout of CISH , the gene for the CIS protein (a...
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Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress
Due to the overexpression or amplification of human epidermal growth factor receptor 2 (HER2) with poor prognosis in a myriad of human tumors, recent...
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Combination of Oncolytic Virotherapy and CAR T/NK Cell Therapy for the Treatment of Cancer
AbstractMultiple lines of evidence indicate that CAR-T cell based therapy and oncolytic virotherapy display robust performance in both...
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Tumor Microenvironment: A Niche for Cancer Stem Cell Immunotherapy
Tumorigenic Cancer Stem Cells (CSCs), often called tumor-initiating cells (TICs), represent a unique subset of cells within the tumor milieu. They...
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Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy
Immunotherapy has ushered in an exciting new era for cancer treatment. The recent discovery and success of immune checkpoint blockade and chimeric...
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Bi-order multimodal integration of single-cell data
Integration of single-cell multiomics profiles generated by different single-cell technologies from the same biological sample is still challenging....
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Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics
Purpose of ReviewCryopreservation and its associated freezing and thawing procedures–short “freeze-thawing”–are among the final steps in economically...
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The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy
AbstractChimeric Antigen Receptor (CAR) immunotherapy utilizes genetically-engineered immune cells that express a unique cell surface receptor that...
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Regenerative Medicine in COVID-19 Treatment: Real Opportunities and Range of Promises
Novel coronavirus disease (COVID-19) has attracted much attention around the world due to its rapid transmission among humans and relatively high...
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CAR Cells beyond Classical CAR T Cells: Functional Properties and Prospects of Application
AbstractChimeric antigen receptors (CARs) are genetically engineered receptors that recognize antigens and activate signaling cascades in a cell....
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The therapeutic landscape for cells engineered with chimeric antigen receptors
Despite the global rapid increase in the number of clinical trials employing chimeric antigen receptors (CARs), no comprehensive survey of their...
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Targeted immunotherapy: harnessing the immune system to battle multiple myeloma
Multiple myeloma (MM) remains an incurable hematological malignancy disease characterized by the progressive dysfunction of the patient’s immune...
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Generating hematopoietic cells from human pluripotent stem cells: approaches, progress and challenges
Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the production of blood cells for clinical application. In two...
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Macrophage barrier in the tumor microenvironment and potential clinical applications
The tumor microenvironment (TME) constitutes a complex microenvironment comprising a diverse array of immune cells and stromal components. Within...
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Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Markers that predict response and resistance to chimeric antigen receptor (CAR) T cells in relapsed/refractory multiple myeloma are currently...
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The role of MSCs and CAR-MSCs in cellular immunotherapy
Chimeric antigen receptors (CARs) are widely used by T cells (CAR-T cells), natural killer cells dendritic cells and macrophages, and they are of...
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Nanoparticle-Based Chimeric Antigen Receptor Therapy for Cancer Immunotherapy
Adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) has emerged as an innovative immunotherapy for hematological...
