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Identifying key genes and functionally enriched pathways in acute myeloid leukemia by weighted gene co-expression network analysis
Acute myeloid leukemia (AML) is characterized by the uncontrolled proliferation of myeloid leukemia cells in the bone marrow and other hematopoietic...
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Circ-IP6K2 suppresses tumor progression by modulating the miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma
Renal cell carcinoma (RCC) is a malignant tumor originating from the epithelial cells of the renal tubules. The clear cell RCC subtype is closely...
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Cladistics of Rhipicephalus microplus and laboratory assessment of acaricidal efficacy of different Cassia fistula extracts against R. microplus larvae
The present study aimed to analyze the cladistics and population structure analysis of Rhipicephalus microplus ticks infesting buffaloes in Haryana,...
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Rapid evolution of promoters from germline-specifically expressed genes including transposon silencing factors
BackgroundThe piRNA pathway in animal gonads functions as an ‘RNA-based immune system’, serving to silence transposable elements and prevent...
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Identification, validation and candidate gene analysis of major QTL for Supernumerary spikelets in wheat
BackgroundThe number of spikelets per spike is a key trait that affects the yield of bread wheat ( Triticum aestivum L.). Identification of the QTL...
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Purifying selection drove the adaptation of mitochondrial genes along with correlation of gene rearrangements and evolutionary rates in two subfamilies of Whitefly (Insecta: Hemiptera)
Insect mitochondrial genomes (mitogenomes) are usually represented by a conserved gene order. Whiteflies exhibit gene rearrangement in their...
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A pan-cancer analysis unveiling the function of NR4A family genes in tumor immune microenvironment, prognosis, and drug response
BackgroundNR4A family genes play crucial roles in cancers. However, the role of NR4A family genes in cancers remains paradoxical as they promote or...
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The contribution of silencer variants to human diseases
BackgroundAlthough disease-causal genetic variants have been found within silencer sequences, we still lack a comprehensive analysis of the...
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Knockdown of AMIGO2 suppresses proliferation and migration through regulating PPAR-γ in bladder cancer
PurposeThis study aims to reveal the relationship between AMIGO2 and proliferation, migration and tumorigenicity of bladder cancer, and explore the...
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Exploring the genetic basis of anthracnose resistance in Ethiopian sorghum through a genome-wide association study
BackgroundSorghum anthracnose is a major disease that hampers the productivity of the crop globally. The disease is caused by the hemibiotrophic...
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Integrated proteomic and metabolomic profiling reveals novel insights on the inflammation and immune response in HFpEF
BackgroundThe precise mechanisms leading to the development of heart failure with preserved ejection fraction (HFpEF) remain incompletely defined. In...
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Massively integrated coexpression analysis reveals transcriptional regulation, evolution and cellular implications of the yeast noncanonical translatome
BackgroundRecent studies uncovered pervasive transcription and translation of thousands of noncanonical open reading frames (nORFs) outside of...
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Panpipes: a pipeline for multiomic single-cell and spatial transcriptomic data analysis
Single-cell multiomic analysis of the epigenome, transcriptome, and proteome allows for comprehensive characterization of the molecular circuitry...
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Nano-Se exhibits limited protective effect against heat stress induced poor breast muscle meat quality of broilers compared with other selenium sources
BackgroundAt present, heat stress (HS) has become a key factor that impairs broiler breeding industry, which causes growth restriction and poor meat...
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Dietary restriction promote sperm remodeling in aged roosters based on transcriptome analysis
BackgroundThe breeder rooster has played a pivotal role in poultry production by providing high-quality semen. Typically, fertility peaks between 30...
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Histone H2A deubiquitinase BAP1 is essential for endothelial cell differentiation from human pluripotent stem cells
Polycomb group proteins (PcGs) add repressive post translational histone modifications such as H2AK119ub1, and histone H2A deubiquitinases remove it....
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Constructing lncRNA-miRNA-mRNA networks specific to individual cancer patients and finding prognostic biomarkers
BackgroundThe competitive endogenous RNA (ceRNA) hypothesis suggests that microRNAs (miRNAs) mediate a regulatory relation between long noncoding...
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A global evaluation of mitochondrial DNA diversity and distribution of dromedary, Camelus dromedarius from north-central Saudi Arabia
Knowledge of genetic variability within and among types and breeds of dromedary ( Camelus dromedarius L.) can be a valuable asset in selective...