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Pre-activation of hypoxia-inducible factor 1-α using prolyl hydroxylase domain inhibitors reduces cisplatin-induced nephrotoxicity
Cisplatin is a widely used, highly effective chemotherapy drug that has a critical nephrotoxic side effect associated with acute kidney injury....
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A computational evaluation of FDA medicines’ ability to inhibit hypoxia-inducible factor prolyl hydroxylase-2 (PHD-2) for acute respiratory distress syndrome
COVID-19 infection is associated with a significant fatality rate in individuals suffering from severe acute respiratory distress syndrome (ARDS)....
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Fast Responding Genes to HIF Prolyl Hydroxylase Inhibitors
AbstractThe attempts to elucidate the mechanism of the hypoxic activation of erythropoietin synthesis lead to the discovery of the hypoxia inducible...
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Intracellular Post-Translational Modifications of Collagens
Collagen synthesis involves many post-translational modifications, the collagen-specific intracellular modifications consisting of hydroxylation of...
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Collagen Biosynthesis
Collagen is synthesized in the endoplasmic reticulum (ER) as procollagen, which is the precursor protein that bears propeptide domains at either end...
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Reaction pathway engineering converts a radical hydroxylase into a halogenase
Fe II /α-ketoglutarate (Fe II /αKG)-dependent enzymes offer a promising biocatalytic platform for halogenation chemistry owing to their ability to...
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Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex
The prolyl hydroxylase 3 (PHD3) protein is less abundant in normal oxygen conditions (normoxia) but increases under deficient oxygen condition...
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Pan-Cancer Analysis of P3H1 and Experimental Validation in Renal Clear Cell Carcinoma
Prolyl 3-hydroxylase 1 (P3H1) has been implicated in cancer development, but no pan-cancer analysis has been conducted on P3H1. In this study, for...
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Enhancing wound regeneration potential of fibroblasts using ascorbic acid-loaded decellularized baby spinach leaves
Decellularization of plant tissues is an emerging route to fabricate scaffolds for tissue engineering and regenerative medicine. Although significant...
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Structural optimization of adaptaquin, a HIF prolyl hydroxylase inhibitor
The structural optimization of adaptaquin, viz. , 7-(4-chlorophenyl)[(3-hydroxypyridin-2-yl)amino]methylquinolin-8-ol, a HIF (hypoxia inducible...
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A human protein hydroxylase that accepts D-residues
Factor inhibiting hypoxia-inducible factor (FIH) is a 2-oxoglutarate-dependent protein hydroxylase that catalyses C3 hydroxylations of protein...
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Optimization of trans-4-hydroxyproline synthesis pathway by rearrangement center carbon metabolism in Escherichia coli
Backgroundtrans -4-Hydroxyproline (T-4-HYP) is a promising intermediate in the synthesis of antibiotic drugs. However, its industrial production...
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Systemic Iron Homeostasis
In this chapter, the three important areas of iron absorption and recycling, mechanism of iron reduction and regulation of homeostasis by hepcidin...
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HIF2 ODD-luciferase reporter: the most sensitive assay for HIF prolyl hydroxylase inhibitors
Reporters expressing fusion proteins of HIF2 and HIF3 C-terminal oxygen degradable domain (ODD) with the firefly luciferase, HIF2 ODD-luc and HIF3...
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Expression, characterization, and application potentiality evaluation of recombinant human-like collagen in Pichia pastoris
Collagen is a biofunctional protein that has been widely used in many fields, including but not limited to biomedical, cosmetics and skin care, food,...
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Vitamin C
Vitamin C or ascorbic acid (a 6-carbon lactone) is a water-soluble vitamin, which can donate electrons for different physiological processes. Vitamin...
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High Throughput Screening in Drug Discovery: Problems and Solutions
AbstractWorld-wide introduction of high throughput screening (HTS) methods in drug discovery research did not result in the increased number of novel...
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Effect of Light Irradiation on Sugar, Phenolics, and GABA Metabolism on Postharvest Grape (Vitis vinifera L.) During Storage
The impact of red and blue light-emitting diodes (LEDs) irradiation on the sugar metabolism and γ-aminobutyric acid in postharvest table grapes stored...
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Water-Soluble Vitamins
Water-soluble vitamins are a group of essential dietary components required in small quantities that are defined by their polar nature and are hence...
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Expression, purification and characterisation of a human anti-CDK4 single-chain variable fragment antibody
BackgroundCyclin-dependent kinase 4 (CDK4) when hyperactivated drives development and maintenance of most tumour types, thus prompting its use as an...
