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Intramolecular Cyclization During Bromination of the Quinoline Alkaloid Haplophyllidine
Bromination of the furanoquinoline alkaloid haplophyllidine by molecular bromine and N -bromosuccinimide was accompanied by intramolecular cyclization...
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Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids
Synthesis and intramolecular cyclization of the substituted...
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Spiro 1-Allyl-4-phenyl-3a,4-dihydrobenzo[f]isoindolininum Derivatives by Base-catalyzed Intramolecular Cyclization
AbstractThe base-catalyzed intramolecular cyclization of (dimethyl)- and (diethyl)-(3-phenylprop-2-enyl)(1-phenylhex-5-en-1-yn-3-yl)ammonium and N -(3-phenylprop-2-enyl)-...
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Palladium-Catalyzed Two- or Three-Component Cyclization of Functionalized Allenes
This review summarizes the Pd-catalyzed cyclization of an allene bearing a nucleophilic functionality with an organic or inorganic halide, and the...
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Synthesis, Intramolecular Cyclization, and Anti-inflammatory Activity of Substituted 2-[2-(4-R-Benzoyl)hydrazinylidene]-4-oxobutanoic Acids
AbstractThe substrate scope of the procedure for the synthesis of 2-[2-(4-R-benzoyl)hydrazinylidene]-4-oxobutanoic acids was expanded, and their...
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A simple and efficient synthesis of 1,3,6-trisubstituted pyrazoloquinolines via intramolecular cyclization – optimization studies
In this work, we developed a straightforward and convenient method for the synthesis of substituted pyrazoloquinolines – highly desirable compounds...
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Cyclization of 5,6-Diarylpyrrolo[3,4-d]pyrimidine-2,4-diones into Pyrrolo[1,2-f]phenanthridine Derivatives: Intramolecular C–H Arylation under Ru/NHC Catalysis
AbstractThe cyclization of 5,6-diarylpyrrolo[3,4- d ]pyrimidine-2,4-diones containing a halogen atom in the ortho -position of one of the aryl rings,...
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Synthesis, Intramolecular Cyclization, and Analgesic Activity of Substituted 2-[2-(Furancarbonyl)hydrazinylydene]-4-oxobutanoic Acids
AbstractA method was proposed for the synthesis of substituted 2-[2-(furan-2-carbonyl)hydrazinylidene]-4-oxobutanoic acids by the reaction of...
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Revealing the cyclization selectivity in intramolecular [3 + 2] cycloaddition reactions of allenic nitrones from the molecular electron density theory perspective
The intramolecular [3 + 2] cycloaddition (32CA) reactions of allenic nitrones have been studied within the molecular electron density theory (MEDT)...
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Palladium-Catalyzed Cyclization via Carbopalladation and Acylpalladation
Over the past two decades, cyclic carbopalladation and related cyclic acylpalladation of alkenes, allenes, alkynes, and related π complexes...
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Intramolecular Cyclization of ortho-Substituted Chalcones in the Presence of Palladium Complexes with Chiral Bisphosphine Ligands
AbstractThe influence of the ligands and leaving group on the direction and selectivity of the intramolecular arylation of ortho -substituted...
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Synthesis and Intramolecular Cyclization of 2,3-Seco-Lupane Triterpenoids with an Ethylketone Fragment
A 1-cyano-2,3-secolupane derivative with an ethylketone fragment was synthesized from 2-hydroxyoximodihydrobetulonic acid methyl ester via a Grignard...
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Synthesis of Indolo[2,3-b]quinolines via a Visible Light-Induced Intramolecular Oxidative Cyclization and Detosylation
AbstractA transition metal-free, visible light-induced intramolecular oxidative cylclization–detosylation–aromatization was discovered. This...
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Protonated Mesoporous Aluminosilica Nanospheres Boosting Aza-Michael Cyclization and Diels-Alder Reaction
Mesoporous aluminosilica hollow nanospheres were prepared easily, which possess very strong acid site. The heterogeneous catalyst can be utilized in...
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Reactivity of alicyclic 1,5,9-triketones toward five-, six-, and seven-membered rings in acidic medium. Stereochemistry of intramolecular cyclization products
Among nine alicyclic 1,5,9-triketones with differently fused 5-, 6-, and 7-membered rings in the molecule, existing as mixtures of 3–6 diastereomers,...
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Intramolecular reductive Heck reaction in the synthesis of 3,3-disubstituted isoindolin-1-ones
An efficient approach to the synthesis of 3,3-disubstituted isoindolinones by intramolecular cyclization of enamides in the presence of the Pd(OAc) 2 /Ph...
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Synthesis, Intramolecular Cyclization, and Antinociceptive Activity of Substituted 2-[2-(4-Nitrobenzoyl)hydrazinylidene]-4-oxobut-2-enoic Acids
AbstractNew substituted 2-[2-(4-nitrobenzoyl)hydrazinylidene]-4-oxobut-2-enoic acids have been synthesized by condensation of 4-nitrobenzohydrazide...
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Allylcopper(I) Isomerization-Enabled Copper(I)-Catalyzed Intramolecular Alkylboration of Terminal Allenes
A cyclobutane ring is one of the important skeletons in pharmaceutical molecules. However, the construction is challenging due to the strain of the...
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Palladium mediated domino heck redox cyclization of aromatic homoallylic alcohols to methylindanones
3-Methyl indanones are key synthetic building blocks for a variety of natural and useful synthetic compounds. Their synthesis is exceedingly...
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Synthesis and Intramolecular Cyclization of Substituted 4-(Het)aryl-4-oxo-2-thienylaminobut-2-enoic Acids Containing Nitrile Group in the Thiophene Ring
AbstractA method for the synthesis of substituted 4-(het)aryl-4-oxo-2-thienylaminobut-2-enoic acids containing a nitrile substituent in the thiophene...