Search
Search Results
-
Analysis of protein secretion in Bacillus subtilis by combining a secretion stress biosensor strain with an in vivo split GFP assay
BackgroundBacillus subtilis is one of the workhorses in industrial biotechnology and well known for its secretion potential. Efficient secretion of...
-
Checkpoint kinase 2 controls insulin secretion and glucose homeostasis
After the discovery of insulin, a century ago, extensive work has been done to unravel the molecular network regulating insulin secretion. Here we...
-
A Guide to the Quantitation of Protein Secretion Dynamics at the Single-Cell Level
Protein secretion is a key cellular functionality, particularly in immunology, where cells can display large heterogeneity in this crucial activity...
-
Secretion of functional interferon by the type 3 secretion system of enteropathogenic Escherichia coli
BackgroundType I interferons (IFN-I)—a group of cytokines with immunomodulatory, antiproliferative, and antiviral properties—are widely used as...
-
Protein overproduction alters exosome secretion in Chinese hamster ovary cells
Despite the abundance of available cell lines, nearly 70% of all recombinant therapeutic proteins today are produced in Chinese hamster ovary (CHO)...
-
Production and secretion of recombinant spider silk in Bacillus megaterium
BackgroundSilk proteins have emerged as versatile biomaterials with unique chemical and physical properties, making them appealing for various...
-
Develo** a platform for secretion of biomolecules in Mycoplasma feriruminatoris
BackgroundHaving a simple and fast dividing organism capable of producing and exposing at its surface or secreting functional complex biomolecules...
-
Cellular ATP redistribution achieved by deleting Tgparp improves lignocellulose utilization of Trichoderma under heat stress
BackgroundThermotolerance is widely acknowledged as a pivotal factor for fungal survival across diverse habitats. Heat stress induces a cascade of...
-
A comprehensive review on phytochemicals as potential therapeutic agents for stress-induced gastric ulcer
Gastric ulcers are the most common chronic gastrointestinal tract disorders, marked by an inflamed break of the mucus membrane covering the...
-
Enhancing menaquinone-7 biosynthesis through strengthening precursor supply and product secretion
Menaquinone-7 (MK-7) is an important class of vitamin K2 that is essential in human health and can prevent osteoporosis and cardiovascular disease....
-
Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach
The probiotic yeast Saccharomyces boulardii ( Sb ) is a promising chassis to deliver therapeutic proteins to the gut due to Sb ’s innate therapeutic...
-
Stress and Disordered Eating Patterns
This chapter provides a review of the relationship between stress and eating behavior, with emphasis on aspects of altered eating patterns in the...
-
Enhanced protein secretion in reduced genome strains of Streptomyces lividans
BackgroundS. lividans TK24 is a popular host for the production of small molecules and the secretion of heterologous protein. Within its large...
-
TRPM7 mediates endoplasmic reticulum stress and ferroptosis in sepsis-induced myocardial injury
Transient receptor potential melastatin 7 (TRPM7), a non-selective cation channel, was significantly upregulated in the blood of patients with...
-
Engineering heterologous enzyme secretion in Yarrowia lipolytica
BackgroundEukaryotic cells are often preferred for the production of complex enzymes and biopharmaceuticals due to their ability to form...
-
Inhibition of FLT1 Attenuates Neurodevelopmental Abnormalities and Cognitive Impairment in Offspring Caused by Maternal Prenatal Stress
Fms-like tyrosine kinase 1 (FLT1) has been shown to regulate processes such as angiogenesis, neurogenesis, and cognitive impairment. However, the...
-
Calcium signaling positively regulates cellulase translation and secretion in a Clr-2-overexpressing, catabolically derepressed strain of Penicillium funiculosum
BackgroundLow-cost cellulase production is vital to sustainable second-generation biorefineries. The catabolically derepressed strain of Penicillium...
-
Antemortem Stress Regulates Postmortem Glycolysis in Muscle by Deacetylation of Pyruvate Kinase M1 at K141
It is well known that preslaughter (antemortem) stress such as rough handling, transportation, a negative environment, physical discomfort, lack of...
-
Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and β-arrestin-1 Pathways
Melanocortin-4 receptor (MC4R) plays an important role in energy balance regulation and insulin secretion. It has been demonstrated that in the...
-
Survival strategies of Listeria monocytogenes to environmental hostile stress: biofilm formation and stress responses
Listeria monocytogenes is a critical foodborne pathogen that causes listeriosis and threatens public health. This pathogenic microorganism forms a...
