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Destabilization of the Alzheimer’s amyloid-β peptide by a proline-rich β-sheet breaker peptide: a molecular dynamics simulation study
The amyloid-β peptide exists in the form of fibrils in the plaques found in the brains of patients with Alzheimer’s disease. One of the therapeutic...
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LATS2 condensates organize signalosomes for Hippo pathway signal transduction
Biomolecular condensates have been proposed to mediate cellular signaling transduction. However, the mechanism and functional consequences of signal...
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Structural basis for translation inhibition by the glycosylated drosocin peptide
The proline-rich antimicrobial peptide (PrAMP) drosocin is produced by Drosophila species to combat bacterial infection. Unlike many PrAMPs, drosocin...
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Toxoplasma Gondii Importin α Shows Weak Auto-Inhibition
Importin α is a nuclear transporter that binds to nuclear localization signals (NLSs), consisting of 7–20 positively charged amino acids found within...
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A linker of the proline-threonine repeating motif sequence is bimodal
The linker of the endoglucanase from Xanthomonas campestris pv. campestris ((PT) 12 ) has a specific sequence, a repeating proline-threonine motif. In...
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Genome-wide identification and analyses of the AHL gene family in rice (Oryza sativa)
AHL (AT-HOOK MOTIF CONTAINING NUCLEAR LOCALIZED) family members play a critical role in stress resistance regulation by DNA–protein and...
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Cyclotides—Cyclic and Disulfide-Knotted Polypeptides
In this chapter we describe the topological features of selected ribosomally synthesized cyclic peptides from plants and animals. These peptides are...
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Knockout of OsPRP1, a gene encoding proline-rich protein, confers enhanced cold sensitivity in rice (Oryza sativa L.) at the seedling stage
Proline-rich proteins (PRPs) play multiple physiological and biochemical roles in plant growth and stress response. In this study, we reported that...
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N-Linked Glycoproteome Analysis of Diosorea alata Tuber Shows Atypical Glycosylation and Indicates Central Role of Glycosylated Proteins in Tuber Maturation
Glycosylation is an important post translational modification in plants. First analysis of N-linked glycosylated proteins of Dioscorea alata using...
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Intracellular Post-Translational Modifications of Collagens
Collagen synthesis involves many post-translational modifications, the collagen-specific intracellular modifications consisting of hydroxylation of...
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Structural basis of colibactin activation by the ClbP peptidase
Colibactin, a DNA cross-linking agent produced by gut bacteria, is implicated in colorectal cancer. Its biosynthesis uses a prodrug resistance...
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Regulation of ThermoTRP Channels by PIP2 and Cholesterol
Transient receptor potential (TRP) ion channels are proteins that are expressed by diverse tissues and that play pivotal functions in physiology....
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The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein
Co-translational folding is crucial to ensure the production of biologically active proteins. The ribosome can alter the folding pathways of nascent...
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Bioactive Compounds from Food and Their Applications in the Treatment of Type 2 Diabetes
The occurrence of insulin and glucose metabolism disorders (collectively referred to as Diabetes), are increasing globally with expectations that...
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Harnessing transaminases to construct azacyclic non-canonical amino acids
Non-canonical amino acids (ncAAs) are prized building blocks in the synthesis of natural products, designer peptides and drug molecules. Despite...
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Lipopeptides as tools in catalysis, supramolecular, materials and medicinal chemistry
Lipopeptides are amphiphilic peptides in which an aliphatic chain is attached to either the C or N terminus of peptides. Their self-assembly — into...
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Modular and diverse synthesis of amino acids via asymmetric decarboxylative protonation of aminomalonic acids
Stereoselective protonation is a challenge in asymmetric catalysis. The small size and high rate of transfer of protons mean that face-selective...
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Composition of the Extracellular Matrix
Following extraction, purification, and in-depth biochemical and functional characterization of a large number of the constituting proteins, it is...
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Phosphorylation of Tau Protein by CDK2/cyclin A and GSK3β Recombinant Kinases: Analysis of Phosphorylation Patterns by Nuclear Magnetic Resonance Spectroscopy
Posttranslational modifications (PTMs) of proteins can be investigated by Nuclear Magnetic Resonance (NMR) spectroscopy as a powerful analytical tool...
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Design of short peptides and peptide amphiphiles as collagen mimics and an investigation of their interactions with collagen using molecular dynamics simulations and docking studies
Short peptide sequences and bolaamphiphiles derived from natural proteins are gaining importance due to their ability to form unique nanoscale...
