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Antisense DNA cocktail therapy using short ß-1,3-glucan/oligonucleotide complexes
Develo** an appropriate delivery vehicle for antisense oligonucleotides (AS-ODNs) to improve efficiency has been a central issue for translating...
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Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents
Oligonucleotide drugs represent an emerging area in the pharmaceutical industry. Solid-phase synthesis generates many structurally closely related...
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Simultaneous analysis of multiple oligonucleotides by temperature-responsive chromatography using a poly(N-isopropylacrylamide)-based stationary phase
Oligonucleotide therapeutics have contributed remarkably to healthcare, being well suited for the treatment of intractable diseases that are...
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Investigation of factors influencing the separation of diastereomers of phosphorothioated oligonucleotides
This study presents a systematic investigation of factors influencing the chromatographic separation of diastereomers of phosphorothioated pentameric...
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Accessible light-controlled knockdown of cell-free protein synthesis using phosphorothioate-caged antisense oligonucleotides
Controlling cell-free expression of a gene to protein with non-invasive stimuli is vital to the future application of DNA nanodevices and synthetic...
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Nanomedicine Applied to Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD) includes Crohn’s disease (CD), ulcerative colitis (UC) and indeterminate colitis. IBD is a diverse disorder with...
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Bridging biological samples to functional nucleic acid biosensor applications: current enzymatic-based strategies for single-stranded DNA generation
The escalating threat of emerging diseases, often stemming from contaminants and lethal pathogens, has precipitated a heightened demand for...
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Phosphorothioate Nucleic Acids: Artificial Modification Envisaged by Nature
Internucleotide phosphate diester bonds in unmodified oligonucleotides are rapidly degraded by nucleolytic enzymes in cells or body fluids. This...
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Phosphorothioate Nucleic Acids: Artificial Modification Envisaged by Nature
Internucleotide phosphate diester bonds in unmodified oligonucleotides are rapidly degraded by nucleolytic enzymes in cells or body fluids. This...
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Hexitol Nucleic Acid (HNA): From Chemical Design to Functional Genetic Polymer
Chemically modified nucleic acids have become crucial tools across a diverse range of sciences. They are extensively used not only as diagnostic and...
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Oncogene-targeting nanoprobes for early imaging detection of tumor
Malignant tumors have been one of the major reasons for deaths worldwide. Timely and accurate diagnosis as well as effective intervention of tumors...
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Hexitol Nucleic Acid (HNA): From Chemical Design to Functional Genetic Polymer
Chemically modified nucleic acids have become crucial tools across a diverse range of sciences. They are extensively used not only as diagnostic and...
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The Effects of FANA Modifications on Non-canonical Nucleic Acid Structures
Initially explored for its antiviral applications, the 2′-deoxy-2′-fluoroarabino nucleoside is now widely incorporated into oligonucleotides for...
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Exploring the diverse biomedical applications of programmable and multifunctional DNA nanomaterials
DNA nanoparticles hold great promise for a range of biological applications, including the development of cutting-edge treatments and diagnostic...
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The Effects of FANA Modifications on Non-canonical Nucleic Acid Structures
Initially explored for its antiviral applications, the 2′-deoxy-2′-fluoroarabino nucleoside is now widely incorporated into oligonucleotides for...
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Effective Separation for New Therapeutic Modalities Utilizing Temperature-responsive Chromatography
In recent years, drug discovery and therapeutics trends have shifted from a focus on small-molecule compounds to biopharmaceuticals, genes, cell...
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Therapeutic Potential of CPPs
Here, the brief summary of therapeuticTherapeutic developments and current situation with applications of CPPs is presented, hopefully leading to...
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An Insight Into Detection Pathways/Biosensors of Highly Infectious Coronaviruses
The outbreak of COVID-19 pandemic and its consequences have inflicted a substantial damage on the world. In this study, it was attempted to review...
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Synthetic materials at the forefront of gene delivery
The delivery of nucleic acids with transient activity for genetic engineering is a promising methodology with potential applications in the treatment...
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A primerless molecular diagnostic: phosphorothioated-terminal hairpin formation and self-priming extension (PS-THSP)
There are various ways that priming can occur in nucleic acid amplification reactions. While most reactions rely on a primer to initiate...
