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Network Pharmacology to Clarify the Effective Substances and Their Action Mechanisms of Traditional Chinese Medicines
Traditional Chinese medicines (TCMs) were applied to treat various biological diseases with a long history. TCMs are characterized by multiple...
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Untargeted metabolomics-based network pharmacology reveals fermented brown rice towards anti-obesity efficacy
There is a substantial rise in the global incidence of obesity. Brown rice contains metabolic substances that can help minimize the prevalence of...
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Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma
Glioma has a high mortality and can hardly be completely cured. Radix Paeoniae Rubra (RPR) is a prevalent component in traditional Chinese medicine...
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Impact of Clinical Pharmacology on the Modernization of Drug Development and Regulation
This chapter provides a brief history of the influence of clinical pharmacologyClinical pharmacology on modernizing drug regulationDrug regulation...
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Integrated spatial metabolomics and network pharmacology to explore the pharmacodynamic substances and mechanism of Radix ginseng-Schisandra chinensis Herb Couple on Alzheimer’s disease
Radix ginseng and Schisandra chinensis have been extensively documented in traditional Chinese medicine (TCM) for their potential efficacy in...
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Pharmacological Mechanism of Mume Fructus in the Treatment of Triple-Negative Breast Cancer Based on Network Pharmacology
Our study aims to find the relevant mechanism of Mume Fructus in the treatment of triple-negative breast cancer (TNBC) by network pharmacology...
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Regulation of appetite-related neuropeptides by herbal medicines: research using microarray and network pharmacology
Anorexia means loss of appetite and is a state whereby a desire to eat is either reduced or eliminated resulting in reducing or stop** food intake....
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Mechanism of Si Ni San Combined with Astragalus in Treating Hepatic Fibrosis: A Network Pharmacology and Molecular Docking Study
Si Ni San combined with Astragalus (SNSQ) has demonstrated significant efficacy in the treatment of hepatic fibrosis (HF), as confirmed by clinical...
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Loureirin B inhibits Cervical Cancer Development by Blocking PI3K/AKT Signaling Pathway: Network Pharmacology Analysis and Experimental Validation
Loureirin B (LB) is an iconic component of Chinese dragon’s blood that presents anti-cancer effects in gastric cancer and liver cancer. Although LB...
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Network pharmacology and molecular docking: combined computational approaches to explore the antihypertensive potential of Fabaceae species
Hypertension is a major global public health issue, affecting quarter of adults worldwide. Numerous synthetic drugs are available for treating...
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Withaferin A for COVID-19: a Network Pharmacology Approach
COVID-19 has become a global challenge as there are very few treatment options available. This has proved to impact several physiological...
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Antibodies expand the scope of angiotensin receptor pharmacology
G-protein-coupled receptors (GPCRs) are key regulators of human physiology and are the targets of many small-molecule research compounds and...
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HPLC Fingerprint Combined with Chemometrics and Network Pharmacology for Q-Markers Prediction Analysis of Saposhnikovia divaricata
Saposhnikovia divaricata (SD) has high medicinal and edible value, but relatively little research has been done on its quality markers (Q-markers)....
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Investigating the potential of mono-chalcone compounds in targeting breast cancer receptors through network pharmacology, molecular docking, molecular dynamics simulation, antiproliferative effects, and gene expressions
The study aims to investigate various aspects of synthesized mono-chalcone compounds 5 and 8 concerning breast cancer, including network...
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Phloretin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology
Phloretin is a dihydrochalcone found in various plant sources such as apples, strawberries, kumquat, pears, honeybush, and sweet tea. Numerous...
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Marine Pharmacology: Potentialities in the Treatment of Infectious Diseases, Osteoporosis and Alzheimer's Disease
Several molecules isolated from various marine organisms (microorganisms, algae, fungi, invertebrates, and vertebrates) are currently under study...
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Anticancer Effect of Active Component of Astragalus Membranaceus Combined with Olaparib on Ovarian Cancer Predicted by Network-Based Pharmacology
In China, a traditional Chinese medicine formulation called astragalus membranaceus (AM) has been utilised for more than 20 years to treat tumors...
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Exploring the Targets and Molecular Mechanisms of Curcumin for the Treatment of Bladder Cancer Based on Network Pharmacology, Molecular Docking and Molecular Dynamics
Curcumin, a phenolic compound derived from turmeric, has demonstrated anti-tumor properties in preclinical models of various cancers. However, the...
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Pharmacology Options for Bulimia Nervosa
Although psychotherapy is effective for bulimia nervosa (BN), many individuals remain symptomatic after treatment. Therefore, pharmacotherapies have...