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New Molecular Technologies for Oligonucleotide Therapeutics-2: A-Type Nucleic Acid Duplex-Specific Binding Oligocationic Molecules for Oligonucleotide Therapeutics
In this chapter, A-type nucleic acid duplex-specific binding oligocationic molecules are introduced as a promising method for improving the...
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New Molecular Technologies for Oligonucleotide Therapeutics-2: A-Type Nucleic Acid Duplex-Specific Binding Oligocationic Molecules for Oligonucleotide Therapeutics
In this chapter, A-type nucleic acid duplex-specific binding oligocationic molecules are introduced as a promising method for improving the...
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Controlled Intracellular Trafficking and Gene Silencing by Oligonucleotide-Signal Peptide Conjugates
Oligonucleotide conjugates have been receiving increasing attention as therapeutic agents. It is well known that oligonucleotide conjugates have some...
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Unraveling Bacterial Single-Stranded Sequence Specificities: Insights from Molecular Dynamics and MMPBSA Analysis of Oligonucleotide Probes
We utilized molecular dynamics (MD) simulations and Molecular Mechanics Poisson–Boltzmann Surface Area (MMPBSA) free energy calculations to...
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Detection of the phosphorothioate oligonucleotide fomivirsen using a ligase detection reaction with polymerase chain reaction
This study aimed to develop a simple and sensitive detection method for fomivirsen, a 21-nucleotide phosphorothioate oligonucleotide used as a...
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Enzyme-Linked Oligonucleotide Assay (ELONA)
Aptamers are single-stranded oligonucleotides able to recognize a target with high affinity and specificity. Aptamers are used in different...
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A Unique Oligonucleotide Probe Hybrid on Graphene Decorated Gold Nanoparticles Modified Screen-Printed Carbon Electrode for Pork Meat Adulteration
A new oligonucleotide-based electrochemical biosensor was developed to detect the Sus scrofa mitochondrial cytochrome b ( cytb ) gene based on an in...
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Controlled Intracellular Trafficking and Gene Silencing by Oligonucleotide-Signal Peptide Conjugates
Oligonucleotide conjugates have been receiving increasing attention as therapeutic agents. It is well known that oligonucleotide conjugates have some...
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New Molecular Technologies for Oligonucleotide Therapeutics-1: Properties and Synthesis of Boranophosphate DNAs
Boranophosphate DNAAntisense oligonucleotides are one of the most successful modalities of oligonucleotide therapeutics. The significant progress on...
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New Molecular Technologies for Oligonucleotide Therapeutics-1: Properties and Synthesis of Boranophosphate DNAs
Boranophosphate DNA Antisense oligonucleotides are one of the most successful modalities of oligonucleotide therapeutics. The significant progress...
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Advanced preparation of fragment libraries enabled by oligonucleotide-modified 2′,3′-dideoxynucleotides
The ever-growing demand for inexpensive, rapid, and accurate exploration of genomes calls for refinement of existing sequencing techniques. The...
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Profiling the interactome of oligonucleotide drugs by proximity biotinylation
Drug-ID is a novel method applying proximity biotinylation to identify drug–protein interactions inside living cells. The covalent conjugation of a...
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A smartphone-based platform for ratiometric visualization of SARS-CoV-2 via an oligonucleotide probe
COVID-19 necessitates the development of reliable and convenient diagnostic tools. In this work, a facile 3D-printed smartphone platform was...
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Coumarin 6H-fused fluorescent probe for highly sensitive detection of coralyne using oligonucleotide-modified silver nanoparticles
In this study, a novel, rapid, and sensitive fluorescence sensing platform was developed for the detection of coralyne (COR) by the conjugation of...
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Programmable Oligonucleotide-Peptide Complexes: Synthesis and Applications
Nucleic acids form biological blueprint and polypeptides assist life activities, both of which are indispensable to organisms. Recently,...
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Detection of Mutations in Rifampin-Resistant Mycobacterium Tuberculosis by Short Oligonucleotide Ligation Assay on DNA Chips (SOLAC)
A new approach, a short oligonucleotide ligation assay on DNA chips (SOLAC) is developed to detect DNA mutations. The SOLAC approach can be carried...
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Scanning Probe Microscopy Studies of Surface-Immobilised DNA/Oligonucleotide Molecules
Although most in vivo biomolecular recognition occurs in solution, in many practical situations (e.g., diagnostics, drug discovery and biosensing)...
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Polyelectrolyte Complexes and Coacervates Formed by De novo-Designed Peptides and Oligonucleotide
The liquid-liquid phase separation of biopolymers in living cells contains multiple interactions and occurs in a dynamic environment. Resolving the...
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Synthesis and application of stationary phase for DNA-affinity chromatographic analysis of unmodified and antisense oligonucleotide
The goal of the research was the synthesis and application of an oligonucleotide immobilized stationary phase for the analysis of unmodified and...
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Improved PCR by the Use of Disruptors, a New Class of Oligonucleotide Reagents
As a powerful tool, polymerase chain reaction (PCR) has been indispensable and widely used in a large array of applications. In practice, many...