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In Vivo Immunomodulatory Study of Postbiotics in Mice
The ultimate property of postbiotics is associated with immunomodulatory activities. They play three important roles in stimulating the immune...
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Metaproteomics of Gut Fungi in Gnotobiotic Mice
Intestinal fungi are a fundamental component of the gut microbiome and play important roles in mammalian host biology. At the same time, the...
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Noncanonical Amino Acid Incorporation in Mice
Genetic code expansion enables in cellulo biosynthesis of curative proteins with enhanced specificity, improved stability, and even novel functions,...
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Generation of Conditional KO Mice of CCN2 and Its Function in the Kidney
CCN2 has been shown to be closely involved in the progression of renal fibrosis, indicating the potential of CCN2 inhibition as a therapeutic target....
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Hyperoside ameliorates depression-like behavior in ovariectomized mice
The physiological changes caused by the decline in estrogen levels due to menopause are linked to an increased risk of depression. This study...
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Detection of Glymphatic Outflow of Tau from Brain to Cerebrospinal Fluid in Mice
Glymphatic system denotes a brain-wide pathway that eliminates extracellular solutes from brain. It is driven by the flow of brain interstitial fluid...
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OT-I TCR Transgenic Mice to Study the Role of PTPN22 in Anti-cancer Immunity
Phosphotyrosine phosphatase non-receptor type 22 (PTPN22) is a key regulator of immune cell activation and responses. Genetic polymorphisms of PTPN22...
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Comparative evaluation of fermented ginseng on alleviating antibiotic-associated diarrhea in mice
Antibiotic associated diarrhea (AAD) was a common side effect of antibiotics, and fermented ginseng exhibited potential in treating AAD. In this...
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Weight regain, but not weight loss exacerbates hepatic fibrosis during multiple weight cycling events in male mice
PurposeWeight cycling is a phenomenon characterized by fluctuating body weight that is commonly observed in individuals employing intentional weight...
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Postnatal Tamoxifen Exposure Induces Long-Lasting Changes to Adipose Tissue in Adult Mice
Tamoxifen (TAM) is commonly administered to a variety of inducible or conditional transgenic mice that contain Cre recombinase fused with ER. While...
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Anti-Allergic and Anti-inflammatory Effects of Bakuchiol on Ovalbumin-Induced Allergic Rhinitis in Mice
Allergic rhinitis (AR) is a prevalent inflammatory disease primarily affecting the nasal mucosa and is caused by allergies. The common symptoms of AR...
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Anti-nociceptive and Anti-inflammatory Activities of Visnagin in Different Nociceptive and Inflammatory Mice Models
Pain management has been a severe public health issue throughout the world. Acute pain if not treated at the appropriate time can lead to chronic...
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An injectable refrigerated hydrogel for inducing local hypothermia and neuroprotection against traumatic brain injury in mice
BackgroundHypothermia is a promising therapy for traumatic brain injury (TBI) in the clinic. However, the neuroprotective outcomes of...
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Sweet taste receptors play roles in artificial sweetener-induced enhanced urine output in mice
Sweet taste receptors found in oral and extra oral tissues play important roles in the regulation of many physiological functions. Studies have shown...
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Agarwood Pill Enhances Immune Function in Cyclophosphamide-induced Immunosuppressed Mice
Agarwood is a resinous wood from the tree in the family Thymelaeaceae . It has been used as traditional medicine in China and Southeast Asia...
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Correlation of Differentially Expressed lncRNAs with Intestinal Flora Imbalance, Small Intestinal Permeability, and Glucose Uptake in T2DM Mice
Diabetes is a major global health concern. This study aimed to investigate the correlation between differentially expressed lncRNAs in mice with type...
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Akkermansia muciniphila postbiotic administration mitigates choline-induced plasma Trimethylamine-N-Oxide production in mice
BackgroundTrimethylamine-N-Oxide (TMAO) is believed to be linked to increased likelihood of cardiovascular disease. While probiotics have shown...
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Hepatoprotective Effect of Annulohypoxylon stygium Melanin on Acute Alcoholic Liver Injury in Mice
Annulohypoxylon stygium melanin (AsM) has various functional properties such as antioxidant and anti-radiation, but its biological activity in vivo...
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Laggera alata Attenuates Inflammatory Response by Regulating Macrophage Polarization in Rheumatoid Arthritis Mice
Rheumatoid arthritis (RA) is a type of joint injury, which can induce the activation of inflammatory factors and polarization of tissue macrophages....
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Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice
A high-methionine (HM) diet leads to hyperhomocysteinemia (HHcy), while gastrointestinal tissue is an important site of net homocysteine (Hcy)...
