Search
Search Results
-
Nerolidol, Bioactive Compound Suppress Growth of HCT-116 Colorectal Cancer Cells Through Cell Cycle Arrest and Induction of Apoptosis
Colon cancer is the most prevalent cancer and causes the highest cancer-associated mortality in both men and women globally. It has a high incidence...
-
Effect of differential deprivation of nutrients on cellular proliferation, oxidative stress, mitochondrial function, and cell migration in MDA-MB-231, HepG2, and HeLa cells
Cancerous cells display metabolic engineering through enhanced utilization of nutrients to support their increased requirements for proliferation,...
-
Antioxidant activities of thermally treated Sesamum indicum L. leaf extracts and their inhibitory effects against growth and metastatic properties of human colon cancer cells
The study aimed to investigate antioxidant activities of two different thermally treated sesame ( Sesamum indicum L.) leaf ethanol extract, steamed...
-
Cucurbitacin IIb Extracted from Hemsleya penxianensis Induces Cell Cycle Arrest and Apoptosis in Bladder Cancer Cells by Regulating Cell Cycle Checkpoints and Mitochondrial Apoptotic Pathway
Cucurbitacin IIb (CuIIb) extracted from Hemsleya penxianensis has been demonstrated anticancer activity in many malignancies, however, its effect...
-
Biomimetic nanovesicle co-delivery system impairs energy metabolism for cancer treatment
Metabolic reprogramming in cancer cells plays a crucial role in cancer development, metastasis and invasion. Cancer cells have a unique metabolism...
-
DB3 from Antarctic lichen inhibits the growth of B16F10 melanoma cells in vitro and in vivo
Malignant melanoma is a fatal disease with an increasing global incidence. Despite numerous studies focused on anti-cancer drugs, a variety of side...
-
CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma
CDCA8 expression is abnormally high in a variety of cancers and involved in the biological process of tumor malignancy. In this study, we discovered...
-
Organosulfur Compound Identified from Striga angustifolia (D. Don) C.J. Saldanha Inhibits Lung Cancer Growth and Induces Apoptosis via p53/mTOR Signaling Pathway
The Striga angustifolia (D. Don) C.J. Saldanha was used as an Ayurvedic and homeopathic medicine for cancer by the tribal peoples of the Maruthamalai...
-
Nogo-B Silencing Expedites the Senescence of Platelet-Derived Growth Factor-BB-Induced Human Hepatic Stellate Cells Via Autophagy
Liver fibrosis is a severe liver pathology in response to chronic or iterative liver injury. Senescence has emerged as a protective mechanism against...
-
KNTC1 knockdown inhibits proliferation and metastases of liver cancer
To investigate the mechanism of kinetochore-associated protein 1 (KNTC1) in hepatocellular carcinoma. To query the TCGA database for KNTC1 expression...
-
Investigation of In Vitro Anti-cancer and Apoptotic Potential of Onion-Derived Nanovesicles Against Prostate and Cervical Cancer Cell Lines
Plant-derived compounds have recently garnered significant interest in the field of medicine due to their rich repertoire of phytochemicals, which...
-
Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties
In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3- c ]isoquinolines based on 4-( N , N -dimethylamino)pheny...
-
Immunomodulatory, Antioxidant, Antiangiogenic, and Antiproliferative Effects of Rice Bran Arabinoxylan
Rice bran arabinoxylan compound (RBAC) is a functional food produced from hydrolysed rice bran denatured with shiitake mushroom enzymes. RBAC...
-
Capparis zeylanica L. root extract promotes apoptosis and cell cycle arrest, inhibits epithelial-to-mesenchymal transition and triggers E-cadherin expression in breast cancer cell lines
Capparis zeylanica L. is a climbing shrub distributed in Indian subcontinent and Mediterranean region. Almost all parts of the plant are used in folk...
-
Biomimetic MDSCs membrane coated black phosphorus nanosheets system for photothermal therapy/photodynamic therapy synergized chemotherapy of cancer
Photothermal therapy is favored by cancer researchers due to its advantages such as controllable initiation, direct killing and immune promotion....
-
Bosutinib high density lipoprotein nanoformulation has potent tumour radiosensitisation effects
Disruption of the cell cycle is among the most effective approach to increase tumour cells’ radio-sensitivity. However, the presence of dose-limiting...
-
13-Cis Retinoic Acid Induces Neuronal Differentiation in Daoy (Medulloblastoma) Cells Through Epigenetic Regulation of Topoisomerase IIβ
Medulloblastoma (MB) is a malignant tumor of the cerebellum that occurs in children and infants. Abnormal neuronal differentiation can lead to brain...
-
Structure-based virtual screening for identification of potential CDC20 inhibitors and their therapeutic evaluation in breast cancer
Cell division cycle 20 (CDC20), a critical partner of anaphase promoting complex (APC/C), is indispensably required for metaphase-to-anaphase...
-
Synthesis, Characterization of C-Zn/Pd-Np as Potential Nanocomposites Against Human Lung Cancer Cells (A549) and Pathogenic Microorganisms
Palladium wrapped ZnO nanocomposites synthesis through carrageenan were made as bimetallic nanocomposites (C-Zn/Pd-Np) and their antibacterial and...
-
Novel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization
In the present study, we explored the potential of coumarin-based compounds, known for their potent anticancer properties, by designing and...
