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Loureirin B inhibits Cervical Cancer Development by Blocking PI3K/AKT Signaling Pathway: Network Pharmacology Analysis and Experimental Validation
Loureirin B (LB) is an iconic component of Chinese dragon’s blood that presents anti-cancer effects in gastric cancer and liver cancer. Although LB...
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HELLS Knockdown Inhibits the Malignant Progression of Lung Adenocarcinoma Via Blocking Akt/CREB Pathway by Downregulating KIF11
Lung adenocarcinoma (LUAD) is a malignant tumor with the characteristics of progressive advancement and high mortality rate worldwide. We aimed to...
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Cell Proliferation and Apoptosis-Related Genes Affect the Development of Human Nasopharyngeal Carcinoma Through PI3K/AKT Signaling Pathway
Nasopharyngeal carcinoma (NPC) is one of the common malignant tumors in China, which occurs on the top and sidewalls of the nasopharyngeal cavity....
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Simvastatin Induces Apoptosis And Suppresses Hepatocellular Carcinoma Induced In Rats
Hepatocellular carcinoma (HCC) is a frequent primary aggressive cancer, a crucial cause of cancer-related mortality globally. Simvastatin is a...
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Targeting apoptosis; design, synthesis and biological evaluation of new benzoxazole and thiazole based derivatives
Several novel approaches to target Bcl-2 proteins and apoptotic pathways have been identified in recent years for the treatment of different types of...
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Rotenone: Advances on Resources, Biosynthetic Pathway, Bioavailability, Bioactivity, and Pharmacology
Rotenone is an important isoflavone occurring in plants belonging to the Leguminosae family, especially in the genera Lonchocarpus, Millettia,...
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Diosmin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology
This chapter will cover the advancement in the research on diosmin, based, mainly, in the last two decades. Diosmin, a flavone glycoside belonging to...
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Effects of Isoflurane on the Cell Pyroptosis in the Lung Cancer Through the HMGB1/RAGE Pathway
There are many common malignant tumors in clinic. Among them, lung cancer is caused by the failure of suction system, which seriously threatens the...
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Initiation of Apoptotic Pathway by the Cell-Free Supernatant Synthesized from Weissella cibaria Through In-Silico and In-Vitro Methods
Globally, colorectal cancer is the most prevalent type of cancer. Even though multiple treatments such as surgery, radiation, chemotherapy, and...
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Noscapinoids: A Family of Microtubule-Targeted Anticancer Agent
Noscapine (C22H23NO7), benzylisoquinoline alkaloid was reported to bind tubulin, limiting the process of division of cells at mitosis without...
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Static magnetic field regulates proliferation, migration, and differentiation of human dental pulp stem cells by MAPK pathway
Magnetic materials are now commonly used in dental clinics. These materials generally produce a static magnetic field (SMF). While it is known that...
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Explore Key Genes and Mechanisms Involved in Colon Cancer Progression Based on Bioinformatics Analysis
To explore underlying mechanisms related to the progression of colon cancer and identify hub genes associated with the prognosis of patients with...
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Protective effect and mechanism research of Phyllanthus emblica Linn. fruit extract on UV-induced photodamage in keratinocytes
Ultraviolet (UV) irradiation causes acute and chronic cutaneous effects that may result in photodamage and photoaging. Epidermis keratinocytes, as...
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CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma
CDCA8 expression is abnormally high in a variety of cancers and involved in the biological process of tumor malignancy. In this study, we discovered...
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Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma
Glioma has a high mortality and can hardly be completely cured. Radix Paeoniae Rubra (RPR) is a prevalent component in traditional Chinese medicine...
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Bioinformatics Research and qRT-PCR Verify Hub Genes and a Transcription Factor-MicroRNA Feedback Network in Intervertebral Disc Degeneration
The present study explores the potentials of bioinformatics analysis to identify hub genes linked to intervertebral disc degeneration (IDD) and...
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Afrormosin exerts an anticancer effect via MAPK and AKT signaling pathways in B16F10 cells
Melanoma is a deadly skin cancer with high mortality, and its incidence is increasing every year. Although numerous anticancer drugs have been...
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Investigation of In Vitro Anti-cancer and Apoptotic Potential of Onion-Derived Nanovesicles Against Prostate and Cervical Cancer Cell Lines
Plant-derived compounds have recently garnered significant interest in the field of medicine due to their rich repertoire of phytochemicals, which...
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New Frontiers on Intracellular cGAS Activation: Molecular Mechanisms, Cellular Signaling, and Therapeutic Strategies
Cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a pivotal role in the innate immune system. As the primary DNA sensor in cells, cGAS binds to dsDNA in...
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Efficient Stable Cell Line Generation of Survivin as an In Vitro Model for Specific Functional Analysis in Apoptosis and Drug Screening
Recognizing proteins that lead to a decreased efficiency of treatment in cancer cells constitutes a main goal for biomedical and biotechnological...
