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Enzymatic synthesis of mono- and trifluorinated alanine enantiomers expands the scope of fluorine biocatalysis
Fluorinated amino acids serve as an entry point for establishing new-to-Nature chemistries in biological systems, and novel methods are needed for...
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Alanine dehydrogenases from four different microorganisms: characterization and their application in L-alanine production
BackgroundAlanine dehydrogenase (AlaDH) belongs to oxidoreductases, and it exists in several different bacteria species and plays a key role in...
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Targeting multi-drug-resistant Acinetobacter baumannii: a structure-based approach to identify the promising lead candidates against glutamate racemase
ContextAcinetobacter baumannii , one of the critical ESKAPE pathogens, is a highly resilient, multi-drug-resistant, Gramnegative, rod-shaped, highly...
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d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition
The broad-spectrum antibiotic d -cycloserine (DCS) is a key component of regimens used to treat multi- and extensively drug-resistant tuberculosis....
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Novel Genes Involved in Cephalosporin Biosynthesis: The Three-component Isopenicillin N Epimerase System
Cephalosporin is one of the best β-lactam antibiotics, widely used in the treatment of infectious diseases. It is synthesized by Acremonium...
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Biochemistry and General Genetics of Nonribosomal Peptide Synthetases in Fungi
Peptides like penicillin or cyclosporin are nonribosomally synthesised by large multifunctional enzymes. Peptide synthetase genes are coexpressed...
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Enzymatic Synthesis of D-pipecolic Acid by Engineering the Substrate Specificity of Trypanosoma cruzi Proline Racemase and Its Molecular Docking Study
Pipecolic acid is an unnatural amino acid mostly used for pharmaceutical purposes. Pipecolic acid has two types of enantiomers with different roles...
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Trends and Challenges in Enzyme Technology
Several major developments took place in the field of biocatalysis over the past few years. These include the invention of directed evolution...
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Detection and analysis of chiral molecules as disease biomarkers
The chirality of small metabolic molecules is important in controlling physiological processes and indicating the health status of humans. Abnormal...
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The implication of Mycobacterium tuberculosis-mediated metabolism of targeted xenobiotics
Drug metabolism is generally associated with liver enzymes. However, in the case of Mycobacterium tuberculosis ( Mtb ), the causative agent of...
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Genomic and metabolomic analysis of Bacillus licheniformis with enhanced poly-γ-glutamic acid production through atmospheric and room temperature plasma mutagenesis
Poly- γ -glutamic acid is an extracellular polymeric substance with various applications owing to its valuable properties of biodegradability,...
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Synthetic auxotrophs accelerate cell factory development through growth-coupled models
The engineering of microbial cell factories for the production of high-value chemicals from renewable resources presents several challenges,...
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Antibiotics That Inhibit Cell Wall Synthesis
Structure of the bacterial cell wall, the metabolic pathway for the biosynthesis of the cell wall, and various antibiotics affecting the different...
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An outlook on suicide enzyme inhibition and drug design
There have been recent renewed interests in the importance of suicide enzyme inhibition. The principal objective of this review is to investigate all...
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Optimized methyl donor and reduced precursor degradation pathway for seleno-methylselenocysteine production in Bacillus subtilis
BackgroundSeleno-methylselenocysteine (SeMCys) is an effective component of selenium supplementation with anti-carcinogenic potential that can...
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Enzymatic Polymerization to Polysaccharides
Polysaccharides are formed by repeated glycosylations between a sugar donor and a sugar acceptor. This chapter reviews the in vitro synthesis of...
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Microbial Production of Diamines
Diamines have the general structure of a carbon backbone with two amino groups. Their applications in industry are very diverse since they can be...
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Separation and identification of the dl-forms of short-chain peptides using a new chiral resolution labeling reagent
There are several reports of d -amino acids being the causative molecules of serious diseases, resulting in the formation of, for example, prion...
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Neuroprotective activity of selenium nanoparticles against the effect of amino acid enantiomers in Alzheimer’s disease
Alzheimer’s disease (AD), the most prevalent neurodegenerative disease, is characterized by extracellular accumulation of amyloid-beta protein (Aβ),...
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Bioremediation: From Key Enzymes to Practical Technologies
The most well-known bioremediation technology is the decomposition and purification of recalcitrant petroleum-based hydrocarbon contaminants by...