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Formulation and Evaluation of Solid-Self Micro Emulsifying Drug Delivery System (S-SMEDDS) of Agomelatine
AbstractThe aim of this study was to create a solid-self-micro emulsifying drug delivery system (S-SMEDDS) to improve the oral bioavailability of...
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Agomelatine co-crystals with resorcinol and hydroquinone: Preparation and characterization
We prepared and characterized co-crystals of the antidepressant drug agomelatine with pharmaceutically acceptable coformers for enhanced solubility....
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Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles
In recent times, the development of therapeutic products by using nanoparticle technology has given rise to progressive increment in a number of...
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An Overview on Nanocarriers for Nasal Delivery
Nasal delivery has come up as a promising approach to deliver diverse therapeutic agents including small drug molecules to biomacromolecules like...
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N-heterocyclic carbene- and organic photoredox-catalysed meta-selective acylation of electron-rich arenes
meta -Selective functionalization of electron-rich arenes provides a complementary route to that of traditional organic synthesis. In classical...
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Sensitive Spectrophotometric Determination of U(VI) Ion at Trace Level in Water Samples: A Simple and Rapid Homogenous Solvent-Based/In-Situ Solvent Formation Microextraction Based on Synthesized/Characterized Task-Specific Ionic Liquid
The preconcentration of uranium VI (U(VI)) at trace levels in some real water and wastewater samples and its determination by spectrophotometry using...
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3D-printing magnesium–polycaprolactone loaded with melatonin inhibits the development of osteosarcoma by regulating cell-in-cell structures
Melatonin has been proposed as a potent anticarcinogen presents a short half-life for osteosarcoma (OS). Cell-in-cell (CIC) structures play a role in...
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The effects of Levilactobacillus brevis on the physiological parameters and gut microbiota composition of rats subjected to desynchronosis
BackgroundAll living organisms have developed during evolution complex time-kee** biological clocks that allowed them to stay attuned to their...
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Recent green synthetic approaches toward Ullmann reaction: a review
The traditional Ullmann reaction which represents the copper-catalyzed coupling between two aryl halides to build a C–C bond was first reported in...
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Investigating the Molecular Effects of Curcumin by Using Model Membranes
Curcumin (diferuloylmethane, CUR), is an potential agent that is extracted from the rootstalk of the Curcuma longa (turmeric) plant and has...
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Enhanced Topical Delivery of Drugs to the Eye Using Chitosan Based Systems
Topical administration is considered to be the favored route for ocular drug delivery by virtue of drug penetration into the underlying layers of...
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EPA and DHA as markers of nutraceutical treatment response in major depressive disorder
PurposeDepression clinical trials are increasingly studying biomarkers to predict and monitor response to treatment. Assessment of biomarkers may...
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C3 amino-substituted chalcone derivative with selective adenosine rA1 receptor affinity in the micromolar range
AbstractTo identify novel adenosine receptor (AR) ligands based on the chalcone scaffold, herein the synthesis, characterization and in vitro and in...
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Fluorescence behaviour of 2-, 3- and 4-amino-1,8-naphthalimides: effects of the substitution positions of the amino functionality on the photophysical properties
The absorption and fluorescence spectra of a series of 1,8-naphthalimide derivatives incorporating the amino functionality at the 2-, 3- and...
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Advances in the Use of Cyclodextrins as Chiral Selectors in Capillary Electrokinetic Chromatography: Fundamentals and Applications
Capillary electrokinetic chromatography is generally recognized as a versatile and robust capillary electromigration technique for the separation of...
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Development and validation of a dynamic range-extended LC-MS/MS multi-analyte method for 11 different postmortem matrices for redistribution studies applying solvent calibration and additional 13C isotope monitoring
Postmortem redistribution (PMR) is one of numerous problems in postmortem toxicology making correct interpretation of measured drug concentrations...
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Polymorphism in Molecular Crystals and Cocrystals
Polymorphism refers to a compound’s ability to exist in more than one crystalline modification through variations in the solid-state structures. Over...
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Trimer formation of 6-methyl-1,3,5-triazine-2,4-diamine in salt with organic and inorganic acids: analysis of supramolecular architecture
Although the numbers of co-crystals, salts, polymorphs, hydrates, and solvates are growing steadily, trimers that contain both inorganic and organic...
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Design of pharmaceutical cocrystals for drug solubility improvement
The new technology of enhancement of the solubility of poorly soluble drug substances is based on the synthesis and application of cocrystal...
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Insights into binding modes of 5-HT2c receptor antagonists with ligand-based and receptor-based methods
5-hydroxytryptamine-2c (5-HT2c) receptor antagonists have clinical utility in the management of nervous system. In this work, ligand-based and...
