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Enhanced Topical Delivery of Drugs to the Eye Using Chitosan Based Systems

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Chitosan for Biomaterials IV

Part of the book series: Advances in Polymer Science ((POLYMER,volume 288))

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Abstract

Topical administration is considered to be the favored route for ocular drug delivery by virtue of drug penetration into the underlying layers of eye. Targeted delivery of drugs to the ocular tissues especially at the posterior segment of eye is hindered predominantly. Long-term maintenance of therapeutic level of drugs in the ocular tissue (both anterior/posterior segments) is the major specific challenge faced by researchers. Development of novel pharmaceutical formulations may overcome these barriers and imparts therapeutic levels in eye. In this regimen chitosan due to its avoidance of toxicity, biocompatibility, bioadhesion, and permeability-enhancing properties is widely used in ocular topical drug delivery. Chitosan facilitates the transport of drugs to the inner eye or accumulation into the corneal/conjunctival epithelia due to its mucoadhesion and permeation-enhancing properties. In this chapter will be provided insights toward the different ocular barriers, conventional and novel chitosan based ocular topical drug delivery systems. Special emphasis will be made toward the development of chitosan based topical delivery systems for ocular diseases.

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Authors and Affiliations

  1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research Kolkata, Kolkata, India

    Subramanian Natesan & Ravichandiran Vellayutham

  2. Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), University College of Engineering, Anna University, Tiruchirappalli, Tamil Nadu, India

    Venkateshwaran Krishnaswami, Chandrasekar Ponnusamy, Saranya Thekkilaveedu & Ruckmani Kandasamy

  3. Department of Pharmaceutics, DM WIMS College of Pharmacy, DM Wayanad Institute of Medical Science, Wayanad, Kerala, India

    Dhilin Pathayappurakkal Mohanan

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  1. Subramanian Natesan
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  3. Venkateshwaran Krishnaswami
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  4. Chandrasekar Ponnusamy
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  1. Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (University), Kochi, India

    R. Jayakumar

  2. Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai, India

    M. Prabaharan

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Natesan, S. et al. (2021). Enhanced Topical Delivery of Drugs to the Eye Using Chitosan Based Systems. In: Jayakumar, R., Prabaharan, M. (eds) Chitosan for Biomaterials IV. Advances in Polymer Science, vol 288. Springer, Cham. https://doi.org/10.1007/12_2021_105

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