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Directed Synthesis of Biologically Interesting Heterocycles with Squaric Acid (3,4-Dihydroxy-3-cyclobutene-1,2-dione) Based Technology
A variety of methods for organic transformation starting from squaric acid have been developed in this decade. These are based on conversion of...
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Synthesis of Carbolines Possessing Antitumor Activity
Synthetic approaches to a number of carboline derivatives having antitumor activity are described. Representative examples of molecules with...
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Diazo and Diazonium DNA Cleavage Agents: Studies on Model Systems and Natural Product Mechanisms of Action
Diazonium salts have been previously used to cleave DNA via generation of carbon centered radicals and cations. Efforts have been made in the...
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Marine Polyether Compounds
Due to their chemical complexity and potent biological activity, marine polyether compounds produced by marine unicellular algae are of interest to...
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Bioactive Heterocyclic Alkaloids of Marine Origin
Many kinds of alkaloids with extraordinary structures and significant biological activities have been isolated from marine organisms. This work...
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Predicting Pharmacological and Toxicological Activity of Heterocyclic Compounds Using QSAR and Molecular Modeling
Heterocyclic compounds are important as drugs, toxicants, and agrochemicals. In this review, we report the QSAR modeling of pharmacological...
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Biological Organometallic Chemistry of B12
Vitamin B12, the “antipernicious anemia factor” required for human and animal metabolism, was discovered in the late 1940s. B12-derivatives are...
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Medicinal Properties of Organometallic Compounds
Although organometallic compounds are ubiquitous in nature, synthetic organometallic compounds are generally considered to be toxic or...
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Domino Dendrimers
Domino dendrimers have recently been developed and introduced as a potential platform for a single triggered multi-prodrug. Surprisingly, three...
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Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy
The atomic force microscope (AFM) is capable of acquiring a range of structural and physicochemical information on a wide range of biopolymers. The...
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Polymer Genomics
Biological activities of biocompatible synthetic polymers used in drug delivery, gene delivery, vaccine development or biomaterial surface...
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Solid-State Structure, Organizationand Properties of Peptide—Synthetic Hybrid Block Copolymers
Peptide–synthetic hybrid block copolymers are most easily prepared via ring-opening polymerization of α-amino acid N-carboxyanhydrides using...
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In Vitro Enzyme-Induced Vinyl Polymerization
The in vitro enzyme-mediated polymerization of vinyl monomers is reviewed with a scope covering enzymatic polymerization of vitamin C...
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Enzymatic Synthesis of Polyesters via Polycondensation
In vitro synthesis of polyesters by polycondensation using isolated enzymes as catalyst via nonbiosynthetic pathways is reviewed. In most cases,...
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Enzymatic Catalysis in the Synthesis of Polyanilines and Derivatives of Polyanilines
Enzyme catalysis in the synthesis of polyaniline is reviewed. Oxidoreductase enzymes and biomimetic catalysts have been used for the polymerization...
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Synthesis of Bio-Inspired Hybrid PolymersUsing Peptide Synthesis and Protein Engineering
The construction of well-defined hybrid materials consisting of synthetic polymers and (poly)peptides or proteins has attracted much attention in...
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Preparation and Electron Conductivity of DNA-Aligned Cast and LB Films from DNA-Lipid Complexes
We describe here a simple preparation of a DNA-lipid complex that is soluble in organic media, and preparations of DNA-aligned thin films from the...
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Detection of Mutations in Rifampin-Resistant Mycobacterium Tuberculosis by Short Oligonucleotide Ligation Assay on DNA Chips (SOLAC)
A new approach, a short oligonucleotide ligation assay on DNA chips (SOLAC) is developed to detect DNA mutations. The SOLAC approach can be carried...
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Production and Formulation of Adenovirus Vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
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Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...