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Pulmonary Vascular Diseases
Pulmonary vascular diseases or pulmonary vasculopathies represent diseases of pulmonary vasculature that are associated with altered pulmonary...
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Vascular Diseases
This group of diseases is caused by defects in the blood supply. Brain cells are only affected secondarily. In ischemic stroke, all cells die in the...
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Vascular and Degenerative Retinal Diseases
The retina, consisting of ten layers, is the innermost tissue of the eye and serves to capture light stimuli from the outside, transforming them into...
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Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics
Senescence compromises the essential role that the endothelium plays in maintaining vascular homeostasis, so promoting endothelial dysfunction and...
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Development of vascular disease models to explore disease causation and pathomechanisms of rare vascular diseases
As the field of medicine is striving forward heralded by a new era of next-generation sequencing (NGS) and integrated technologies such as...
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AAV-Based Strategies for Treatment of Retinal and Choroidal Vascular Diseases: Advances in Age-Related Macular Degeneration and Diabetic Retinopathy Therapies
Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are vascular diseases with high prevalence, ranking among the leading causes of...
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Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases
BackgroundThis study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2.
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Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers
BackgroundVascular dysfunction was recently reported to be involved in the pathophysiological process of neurodegenerative diseases, but its role in...
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Circular RNAs: regulators of vascular smooth muscle cells in cardiovascular diseases
The aberrant expansion and dysfunction of vascular smooth muscle cells (VSMCs) contribute to the occurrence and development of many cardiovascular...
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Extracellular Vesicles and Vascular Inflammation
Vascular inflammation is the most common pathological feature in the pathogenesis of human disease. It is a complex immune process involved with many...
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Endothelial dysfunction: mechanisms and contribution to diseases
The endothelium, lining the inner surface of blood vessels and spanning approximately 3 m 2 , serves as the largest organ in the body. Comprised of...
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Cuproptosis and copper deficiency in ischemic vascular injury and repair
Ischemic vascular diseases are on the rise globally, including ischemic heart diseases, ischemic cerebrovascular diseases, and ischemic peripheral...
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Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases
BackgroundSmoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. These risk factors...
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Sex Differences in Vascular Function
Sex is an important biological variable that impacts several organism functions at the genetic, molecular, and cellular levels. Sex differences are...
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The role of vasculature and angiogenesis in respiratory diseases
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as...
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Purinergic regulation of pulmonary vascular tone
Purinergic signaling is a crucial determinant in the regulation of pulmonary vascular physiology and presents a promising avenue for addressing lung...
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Fractal Analysis in Neurodegenerative Diseases
Neurodegenerative diseases are defined by progressive nervous system dysfunction and death of neurons. The abnormal conformation and assembly of...
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Batokine in Central Nervous System Diseases
Brown adipose tissue (BAT) is a special type of fat tissue in mammals and is also a key endocrine organ in the human body. Batokine, the endocrine...
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Therapeutics in Metabolic Diseases
Metabolic diseases have important effects on the health and healthcare costs of an individual. It adversely affects various body processes. Metabolic...
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Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia
Angiotensin II (AngII) induces the contraction and proliferation of vascular smooth muscle cells (VSMCs). AngII activates phospholipase C-β (PLC-β),...
