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Endothelial dysfunction: mechanisms and contribution to diseases
The endothelium, lining the inner surface of blood vessels and spanning approximately 3 m 2 , serves as the largest organ in the body. Comprised of...
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The double whammy of ER-retention and dominant-negative effects in numerous autosomal dominant diseases: significance in disease mechanisms and therapy
The endoplasmic reticulum (ER) employs stringent quality control mechanisms to ensure the integrity of protein folding, allowing only properly...
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A Brief Landscape of Epigenetic Mechanisms in Dental Pathologies
AbstractEpigenetics is the study of modifications in DNA expression without changing the sequences in deoxyribonucleic acid. Epigenetic mechanisms...
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The regulating effect of curcumin on NF-κB pathway in neurodegenerative diseases: a review of the underlying mechanisms
Neurodegenerative diseases are part of the central nervous system (CNS) disorders that indicate their presence with neuronal loss, neuroinflammation,...
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Epidemiology of Allergic Airways Diseases
The epidemiology of allergic airways diseases, encompassing asthma and allergic rhinitis, is a complex domain influenced by genetic predispositions,...
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The role of NLRP3 inflammasome in aging and age-related diseases
The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are...
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Drosophila Models of Prion Diseases
Prion diseases encompass a heterogeneous group of fatal brain disorders associated with the accumulation of misfolded isoforms of the prion protein...
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Extracellular Vesicle Biomarkers for Diagnosis of Cardiovascular Diseases
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. There is an urgent need for early detection biomarkers, which will benefit...
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γδ T cells in oral diseases
Objectiveγδ T cells are a distinct subset of unconventional T cells, which link innate and adaptive immunity by secreting cytokines and interacting...
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Micropeptides: origins, identification, and potential role in metabolism-related diseases
With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode...
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Unwinding circular RNA’s role in inflammatory pulmonary diseases
Circular RNAs (circRNAs) have emerged as pivotal regulators of gene expression and cellular processes in various physiological and pathological...
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A Comprehensive Overview of the Neural Mechanisms of Light Therapy
Light is a powerful environmental factor influencing diverse brain functions. Clinical evidence supports the beneficial effect of light therapy on...
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Nanomedicine in the Treatment of Metabolic Diseases
Nanotechnology employed in drug development has led to the origination of enhanced drug delivery systems targeted for the mitigation of metabolic...
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The mechanism of ferroptosis and its related diseases
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for...
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Advancements in Single-Cell RNA Sequencing Research for Neurological Diseases
Neurological diseases are a major cause of the global burden of disease. Although the mechanisms of the occurrence and development of neurological...
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Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases
The glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic NAD + -linked glycerol 3-phosphate dehydrogenase 1 (GPD1) and...
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Exploring the relationship between infectious agents and autoimmune diseases: a review
The relationship between infectious agents and autoimmune diseases is a complex issue. In recent years, increasing clinical cases have indicated that...
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Mechanisms of axonal support by oligodendrocyte-derived extracellular vesicles
Extracellular vesicles (EVs) have recently emerged as versatile elements of cell communication in the nervous system, mediating tissue homeostasis....
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The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases
N6-methyladenosine (m6A) stands as the most prevalent modified form of RNA in eukaryotes, pivotal in various biological processes such as regulating...
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Fractal Analysis in Neurodegenerative Diseases
Neurodegenerative diseases are defined by progressive nervous system dysfunction and death of neurons. The abnormal conformation and assembly of...