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Novel pathogenic variants in CUBN uncouple proteinuria from renal function
BackgroundProteinuria is an unfavorable clinical condition highly associated with a risk of renal and cardiovascular disease in chronic kidney...
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Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study
BackgroundProteinuria is a common finding in dogs with leishmaniosis. Although antileishmanial therapeutic protocols are widely implemented, little...
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Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients
BackgroundHypertension and proteinuria are common bevacizumab-induced toxicities. No validated biomarkers are available for identifying patients at...
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Association between thyroid-stimulating hormone (TSH) and proteinuria in relation to thyroid cyst in a euthyroid general population
BackgroundHigh normal levels of thyroid-stimulating hormone (TSH) have been reported to be associated with chronic kidney disease (CKD) among...
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Dipstick proteinuria and risk of type 2 diabetes mellitus: a nationwide population-based cohort study
BackgroundProteinuria has been recognized as a marker of systemic inflammation and endothelial dysfunction associated with insulin resistance and...
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Low Urine Secretion of Semaphorin3A in Lupus Patients with Proteinuria
Immune semaphorins are important in controlling both innate and adaptive immune responses. The regulatory role of semaphorin3A (sema3A) in systemic...
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Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM-1 in rats
BackgroundTrimethylamine oxide (TMAO) is a biomarker in cardiovascular and renal diseases. TMAO originates from the oxidation of trimethylamine...
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Proteinuria as a presenting sign of combined methylmalonic acidemia and homocysteinemia: case report
BackgroundDisorders of the metabolism and absorption of vitamin B12 can lead to decrease in activity of methionine synthetase and methylmalonate...
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Correlation between urine ACR and 24-h proteinuria in a real-world cohort of systemic AL amyloidosis patients
A 24-h urine protein collection (24hUP), the gold standard for measuring albuminuria in systemic AL amyloidosis, is cumbersome and inaccurate. We...
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Severe proteinuria during the administration of bevacizumab plus mFOLFOX6 in a colorectal cancer patient after kidney transplantation: a case report
BackgroundBevacizumab (BEV) leads to proteinuria and renal damage. It is not clear whether the administration of immunosuppressive drugs after renal...
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Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study
BackgroundTo date, the association of serum macrophage migration inhibitory factor (MIF) and serum adipokines with lupus nephritis is controversial.
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Longitudinal modeling of efficacy response in patients with lupus nephritis receiving belimumab
Belimumab was approved for active lupus nephritis (LN) in adults in the European Union and patients ≥ 5 years of age in the USA based on a Phase 3,...
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Role of Renin Angiotensin-Aldosterone System in Kidney Homeostasis
The Renin-Angiotensin-Aldosterone System (RAAS), which regulates plasma sodium levels, arterial blood pressure, and extracellular volume, is a...
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Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway
Lupus nephritis (LN) is a kidney disease that occurs after systemic lupus erythematosus (SLE) affects the kidneys. Pentraxin 3 (PTX3) is highly...
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A deletion variant in LMX1B causing nail–patella syndrome in Japanese twins
Nail–patella syndrome (NPS) is a hereditary disease caused by pathogenic variants in LMX1B and characterized by nail, limb, and renal symptoms. This...
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Modeling of clinical phenotypes in systemic lupus erythematosus based on the platelet transcriptome and FCGR2a genotype
BackgroundThe clinical heterogeneity of SLE with its complex pathogenesis remains challenging as we strive to provide optimal management. The...
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Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway
Sirtuins (Sirts) are a family of nicotinamide adenine dinucleotide-dependent protein deacetylases that share diverse cellular functions. Increasing...
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A novel COL4A5 splicing mutation causes alport syndrome in a Chinese family
BackgroundAlport syndrome (AS) is characterised by haematuria, proteinuria, a gradual decline in kidney function, hearing loss, and eye...
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Suitability of reduced dose glucocorticoids therapy regimen for antibody-associated vasculitis patients with TB: a retrospective study
IntentionImmunosuppressive therapy is the major treatment approach for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis...
