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The Interleukin-8 Pathway in Cancer
Interleukin-8 (IL-8), a pro-inflammatory chemotactic cytokine encoded by the CXCL8 gene, is mainly released by macrophages and other immune cells and...
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The Role of Interleukin (IL)-6/IL-6 Receptor Axis in Cancer
As a pleiotropic cytokine, interleukin (IL)-6 plays a key role in mediating the host’s immune defense. Multiple cell types are involved in IL-6...
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Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis
Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work...
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Dissecting Interleukin-6 Classic and Trans-signaling in Inflammation and Cancer
Interleukin-6 (IL-6) is a cytokine synthesized by many cells in the human body. IL-6 binds to a membrane-bound receptor (IL-6R), which is only...
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Higher plasma interleukin − 6 levels are associated with lung cavitation in drug-resistant tuberculosis
BackgroundLung cavitation is associated with heightened TB transmission and poor treatment outcomes. This study aimed to determine the relationship...
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Molecular Engineering of Interleukin-2 for Enhanced Therapeutic Activity in Autoimmune Diseases
The interleukin-2 (IL-2) cytokine plays a crucial role in regulating immune responses and maintaining immune homeostasis. Its immunosuppressive...
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Antiviral response and immunopathogenesis of interleukin 27 in COVID-19
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with...
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Interleukin-1 Antagonists for the Treatment of Recurrent Pericarditis
Although most patients with acute pericarditis will recover, a minority will have recurrent, debilitating episodes. In these patients, refractory...
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The Role of Interleukin-6/GP130 Cytokines in Cancer Cachexia
Cancer cachexia is characterized by the involuntary loss of skeletal muscle with or without adipose tissue loss in the presence of tumor burden. It...
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Interleukin-1 Receptor Antagonist as Therapy for Traumatic Brain Injury
Traumatic brain injury is a common type of acquired brain injury of varying severity carrying potentially deleterious consequences for the afflicted...
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Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds
Non-healing wounds have a negative impact on quality of life and account for many cases of amputation and even early death among patients. Diabetic...
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Interleukin-5 levels in relation to malaria severity: a systematic review
BackgroundThe role of cytokines such as interleukin-5 (IL-5) in the pathogenesis of malaria remains unclear. This systematic review sought to...
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Causal effect of interleukin (IL)-6 on blood pressure and hypertension: A mendelian randomization study
To examine whether circulating interleukin-6 (IL-6) levels (CirIL6) have a causal effect on blood pressure using Mendelian randomization (MR)...
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Silencing DDX3 Attenuates Interleukin-1β-Induced Intervertebral Disc Degeneration Through Inhibiting Pyroptosis
Intervertebral disc degeneration (IVDD) is a common disorder associated with chronic inflammation and cell death. In this study, an IVDD rat model...
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Interleukin 1β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan
Triclosan (TCS) is an antimicrobial compound widely used in personal hygiene products such as mouthwash and toothpaste; and has been found in human...
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Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis
BackgroundThe pathogenesis of rheumatoid arthritis (RA) is an immune imbalance, in which various inflammatory immune cells and pro-inflammatory...
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Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic...
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Targeting interleukin-1β and inflammation in lung cancer
Inflammation is a process that protects organs against various potentially harmful stimuli and enables repair. Dysregulated inflammation, however,...
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Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia
BackgroundHypertriglyceridemia is closely linked to atherosclerosis related inflammatory processes and blood–brain barrier (BBB) dysfunction. Using...
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Whole exome sequencing identified a novel splice donor site variant in interleukin 2 receptor alpha chain
Interleukin 2 receptor alpha chain (IL-2Rα or CD25) deficiency (OMIM #606367) is an immune dysregulation disorder segregating in autosomal recessive...
