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Peripheral immune cells in metastatic breast cancer patients display a systemic immunosuppressed signature consistent with chronic inflammation
Immunotherapies blocking the PD-1/PD-L1 checkpoint show some efficacy in metastatic breast cancer (mBC) but are often hindered by immunosuppressive...
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Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response
BackgroundCurrent treatments for Alzheimer’s disease (AD) have largely failed to yield significant therapeutic benefits. Novel approaches are...
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RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer
BackgroundRecently genome-based studies revealed that the abnormality of Hippo signaling is pervasive in TNBC and played important role in cancer...
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Dysregulated PD-L2 is correlated with disease activity and inflammation in rheumatoid arthritis
The programmed death-1 (PD-1) pathway has been shown to deliver an inhibitory signal, and aberrant expression of the PD-1 molecule and/or its ligand...
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Sex-related differences in serum biomarker levels predict the activity and efficacy of immune checkpoint inhibitors in advanced melanoma and non-small cell lung cancer patients
BackgroundImmune Checkpoint Inhibitors (ICIs) lead to durable response and a significant increase in long-term survival in patients with advanced...
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Secreted indicators of androgen receptor activity in breast cancer pre-clinical models
PurposeAccumulating evidence has attracted attention to the androgen receptor (AR) as a biomarker and therapeutic target in breast cancer. We...
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A vision of immuno-oncology: the Siena think tank of the Italian network for tumor biotherapy (NIBIT) foundation
BackgroundThe yearly Think Tank Meeting of the Italian Network for Tumor Biotherapy (NIBIT) Foundation, brings together in Siena, Tuscany (Italy),...
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A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy
BackgroundThe applicability and therapeutic efficacy of specific personalized immunotherapy for cancer patients is limited by the genetic diversity...
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Intraoperative radiation therapy induces immune response activity after pancreatic surgery
BackgroundPancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and...
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Exploring the Therapeutic Potential of ICOS and GITR Agonists in Lung Cancer
Lung cancer, being the second most prevalent cancer occurring in both males and females in the United States, is one of the most frequently reported...
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Indoleamine 2,3-Dioxygenase Activity-Induced Acceleration of Tumor Growth, and Protein Kinases-Related Novel Therapeutics Regimens
Indoleamine 2,3-dioxygenase (IDO) is overexpressed in response to interferon-gamma (IFN-γ). IDO-mediated degradation of tryptophan (Trp) along the...
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Immune System, Redox Signaling, and Cancer Immunity
This chapter entitled “Immune System, Redox Signaling, and Cancer Immunity” starts with the characteristics of various immune systems (innate and...
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Mechanisms of Resistance to Immunotherapies in Cancer
As the number of indications of cancer immunotherapy, specifically anti–PD-(L)1 therapy, increases and more patients receive anticancer treatment...
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IDO/kynurenine pathway in cancer: possible therapeutic approaches
Cancer is one of the leading causes of death in both men and women worldwide. One of the main changes associated with cancer progression, metastasis,...
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The Promise of Immunotherapeutics and Vaccines in the Treatment of Cancer
The Cancer Moonshot aspires to cut the death rate from cancer by at least 50% over the next 25 years by 2047 and improve the experience of people and...
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Radiation-Induced Immunoediting of Cancer
In the not so distant past, it was believed that for some reason, the immune system fails to recognize a tumor, allowing it to develop and grow....
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Immune Checkpoint Inhibitors and Anti-Angiogenic Therapy for Cancer
The development of increased knowledge of the interaction between cancer cells, immune cells, and the tumor microenvironment is of special interest...
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Expression of Inhibitory Molecules (Arginase-1, IDO, and PD-L1) by Myeloid-Derived Suppressor Cells in Multiple Myeloma Patients in Remission
We studied suppressor potential of myeloid-derived suppressor cells (MDSC) in multiple myeloma patients, including before and after mobilization of...
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Histone Demethylase KDM3 (JMJD1) in Transcriptional Regulation and Cancer Progression
Methylation of histone H3 lysine 9 (H3K9) is a repressive histone mark and associated with inhibition of gene expression. KDM3 is a subfamily of the...
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Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
BackgroundMalignant ascites commonly occurs in advanced or recurrent stages of epithelial ovarian cancer during peritoneal carcinomatosis and is...
