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Immune System, Redox Signaling, and Cancer Immunity

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Redox Regulation and Therapeutic Approaches in Cancer

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Abstract

This chapter entitled “Immune System, Redox Signaling, and Cancer Immunity” starts with the characteristics of various immune systems (innate and adaptive) and immune cells, and their association with cancer cells. Dysfunction of the role of immune systems in diseases has been discussed. The role of ROS and redox regulation in immune system activity through the activation and deactivation of various immune cells has been taken up extensively.

Furthermore, the link between immunity and anticancer strategies has been discussed. Various experimental models to exhibit the interaction of immune cells and also TME cells in various tumor models have been discussed, which provide information on the activation or suppression of immune cells which further may be useful in translating into immunotherapy. In simple terms, cancer cell genomic instability provides neo-antigen, which suppresses the T cell function through the generation of inhibitory molecules such as popular CTLA-4 and PD-1, which were exploited for cancer therapy. The role of TME cells in immune responses to cancer cells has also been taken up. Also, immune metabolism (interplay between immunologic and metabolic processes) where immune system mediates cancer initiation and development has been discussed. Cell intrinsic metabolism directly controls the effector function and cellular fate. Interestingly, suppressed immune activity in an increased ROS situation in the TME was addressed by using nanomaterials to suppress ROS levels and, in turn, enhance immune response.

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    Mohinder Pal Bansal

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Bansal, M.P. (2023). Immune System, Redox Signaling, and Cancer Immunity. In: Redox Regulation and Therapeutic Approaches in Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-99-7342-2_6

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