Search
Search Results
-
A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson’s disease
The dual-hit hypothesis of Parkinson’s disease (PD) originally postulated that a neurotropic pathogen leads to formation of α-synuclein pathology in...
-
Chronic Myelomonocytic Leukaemia: A Three-Hit Malignancy
Gene expression is epigenetically controlled, and the changes in gene expression that drive tumour progression are in some cases epigenetically...
-
Chronic Myeloid Leukaemia: A One-Hit Malignancy
Chronic myeloid leukaemia (CML) is caused by the Bcr-Abl translocation. It is otherwise genetically normal. CML is unusual in being a “single-hit”...
-
Real-world advantage and challenge of post-autologous stem cell transplantation MRD negativity in high-risk patients with double-hit multiple myeloma
BackgroundAutologous stem-cell transplantation (ASCT) remains a beneficial approach for patients with newly diagnosed multiple myeloma (NDMM) in the...
-
Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) causes substantial medical and societal burden with no therapies ameliorating cognitive deficits. Centralized...
-
Whole Blood Procoagulant Platelet Flow Cytometry Protocol for Heparin-Induced Thrombocytopenia (HIT) and Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Testing
Heparin-induced thrombocytopenia (HIT) is a well-characterized, iatrogenic complication of heparin anticoagulation with significant morbidity. In...
-
Neuroimmune multi-hit perspective of coronaviral infection
It is well accepted that environmental stressors experienced over a one’s life, from microbial infections to chemical toxicants to even psychological...
-
Primary breast double-hit lymphoma management and outcomes: a real-world multicentre experience
BackgroundPrimary breast double-hit lymphoma (PB-DHL) is a rare, highly aggressive malignancy that poses challenges regarding accurate diagnosis and...
-
-
Antibody Affinity Maturation Using Computational Methods: From an Initial Hit to Small-Scale Expression of Optimized Binders
Nanobodies (VHHs) are engineered fragments of the camelid single-chain immunoglobulins. The VHH domain contains the highly variable segments...
-
The Influence of Macrophage-Activating Lipopeptide-2 in Regard to Liver-Specific Changes Within a Murine Two-Hit Model
Trauma hemorrhage (TH) and subsequent sepsis are well known to frequently result in severe organ damage. Although macrophage-activating lipopeptide-2...
-
When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers?
AimsWhether and when glomerular filtration rate (GFR) in preterms catches up with term peers is unknown. This study aims to develop a GFR maturation...
-
The Influence of Macrophage-Activating Lipopeptide 2 (MALP-2) on Local and Systemic Inflammatory Response in a Murine Two-Hit Model of Hemorrhagic Shock and Subsequent Sepsis
Pulmonary complications after severe trauma and sepsis remain to be the main cause for adverse outcome. MALP-2 has been described to exert beneficial...
-
High-intensity interval training in allogeneic adoptive T-cell immunotherapy – a big HIT?
BackgroundAdoptive transfer of virus-specific T cells (VSTs) represents a prophylactic and curative approach for opportunistic viral infections and...
-
Outcomes in patients with chronic lymphocytic leukemia and TP53 aberration who received first-line ibrutinib: a nationwide registry study from the Italian Medicines Agency
In this analysis we describe the effectiveness of first-line ibrutinib in 747 patients with chronic lymphocytic leukemia (CLL) and TP53 aberrations...
-
Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease
BackgroundThe relationship between biomarkers of metabolic syndrome and insulin resistance, plasma triglyceride/HDL cholesterol (TG/HDL-C) ratio, on...
-
Know your molecule: pharmacological characterization of drug candidates to enhance efficacy and reduce late-stage attrition
Despite advances in chemical, computational and biological sciences, the rate of attrition of drug candidates in clinical development is still high....
-
TERRA G-quadruplex stabilization as a new therapeutic strategy for multiple myeloma
BackgroundMultiple myeloma (MM) is a hematologic malignancy characterized by high genomic instability, and telomere dysfunction is an important cause...
-
PIK3CA mutations are associated with pathologic complete response rate to neoadjuvant pyrotinib and trastuzumab plus chemotherapy for HER2-positive breast cancer
BackgroundNeoadjuvant treatment with a dual anti-human epidermal growth factor receptor 2 (HER2) blockade with pyrotinib and trastuzumab has been...
