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A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle
Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated...
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CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions
Exposure of lipopolysaccharide triggers macrophage pro-inflammatory polarization accompanied by metabolic reprogramming, characterized by elevated...
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Glutamine Maintains Satellite Glial Cells Growth and Survival in Culture
Satellite glial cells (SGCs) tightly surround neurons and modulate sensory transmission in dorsal root ganglion (DRG). At present, the biological...
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Proof of stability of an RSV Controlled Human Infection Model challenge agent
In 2018, SGS Belgium NV developed RSV-NICA (Respiratory Syncytial Virus-Nasobronchial Infective Challenge Agent), an RSV type A challenge agent for...
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Glutamine Metabolism in Cancer
Metabolism is a fundamental process for all cellular functions. For decades, there has been growing evidence of a relationship between metabolism and...
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Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination
Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their...
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Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge
Current Influenza virus vaccines primarily induce antibody responses against variable epitopes in hemagglutinin (HA), necessitating frequent updates....
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Rice bran oil supplementation protects swine weanlings against diarrhea and lipopolysaccharide challenge
Early weaned piglets suffer from oxidative stress and enteral infection, which usually results in gut microbial dysbiosis, serve diarrhea, and even...
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Therapeutic Targeting of Glutamine Metabolism in Colorectal Cancer
Colorectal cancer is one of the most commonly diagnosed incurable multifactorial malignancies in the world. To date, there are no promising...
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A gH/gL-encoding replicon vaccine elicits neutralizing antibodies that protect humanized mice against EBV challenge
Epstein-Barr virus (EBV) is associated with several malignancies, neurodegenerative disorders and is the causative agent of infectious mononucleosis....
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YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge
Ebola virus (EBOV) and related filoviruses such as Sudan virus (SUDV) threaten global public health. Effective filovirus vaccines are available only...
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Immunization with matrix-, nucleoprotein and neuraminidase protects against H3N2 influenza challenge in pH1N1 pre-exposed pigs
There is an urgent need for influenza vaccines providing broader protection that may decrease the need for annual immunization of the human...
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Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells
Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, play an indispensable role in cancer initiation,...
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A DNA vaccine targeting VEE virus delivered by needle-free jet-injection protects macaques against aerosol challenge
We have previously shown that DNA vaccines expressing codon optimized alphavirus envelope glycoprotein genes protect both mice and nonhuman primates...
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A live-attenuated viral vector vaccine protects mice against lethal challenge with Kyasanur Forest disease virus
Kyasanur Forest disease virus (KFDV) is a tick-borne flavivirus endemic in India known to cause severe hemorrhagic and encephalitic disease in...
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Fluoride Exposure Affects Glutamine Uptake in Müller Glia Cells
Fluoride, a pollutant present in contaminated ground water, oral care products, food, and pesticides, has deleterious effects in the structure and...
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A CpG 1018 adjuvanted neuraminidase vaccine provides robust protection from influenza virus challenge in mice
Influenza virus infections pose a significant threat to global health. Vaccination is the main countermeasure against influenza virus spread,...
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Glutamine Supplementation Attenuates the Inflammation Caused by LPS-Induced Acute Lung Injury in Mice by Regulating the TLR4/MAPK Signaling Pathway
Bacterial infection is one of the main causes of bovine respiratory disease (BRD), which can cause tremendous losses for the herd farming industry...
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Interorgan Metabolism, Nutritional Impacts, and Safety of Dietary L-Glutamate and L-Glutamine in Poultry
L-glutamine (Gln) is the most abundant amino acid (AA) in the plasma and skeletal muscle of poultry, and L-glutamate (Glu) is among the most abundant...
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Expanded usage of the Challenge-Comet assay as a DNA repair biomarker in human populations: protocols for fresh and cryopreserved blood samples, and for different challenge agents
Deficiencies in DNA damage response and repair (DDRR) can cause serious pathological outcomes; therefore, having an ability to determine individual...
