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Current and future therapeutic strategies for high-grade gliomas leveraging the interplay between epigenetic regulators and kinase signaling networks
Targeted therapies, including small molecule inhibitors directed against aberrant kinase signaling and chromatin regulators, are emerging treatment...
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Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas
Malignant gliomas are highly heterogeneous glia-derived tumors that present an aggressive and invasive nature, with a dismal prognosis. The...
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The cuproptosis-related signature predicts the prognosis and immune microenvironments of primary diffuse gliomas: a comprehensive analysis
BackgroundEvidence has revealed a connection between cuproptosis and the inhibition of tumor angiogenesis. While the efficacy of a model based on...
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High expression of RTEL1 predicates worse progression in gliomas and promotes tumorigenesis through JNK/ELK1 cascade
Gliomas are the most common primary intracranial tumor worldwide. The maintenance of telomeres serves as an important biomarker of some subtypes of...
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Notch signaling in malignant gliomas: supporting tumor growth and the vascular environment
Glioblastoma is the most malignant form of glioma, which is the most commonly occurring tumor of the central nervous system. Notch signaling in...
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Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas
BackgroundThe complement inhibitor CSMD1 acts as a tumor suppressor in various types of solid cancers. Despite its high level of expression in the...
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The Significant Role of microRNAs in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application
MicroRNAs (miRNAs) are non-coding RNAs with only 20–22 nucleic acids that inhibit gene transcription and translation by binding to mRNA. MiRNAs have...
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K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Canonical (H3.1/H3.2) and noncanonical (H3.3) histone 3 K27M-mutant gliomas have unique spatiotemporal distributions, partner alterations and...
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HELLPAR/RRM2 axis related to HMMR as novel prognostic biomarker in gliomas
BackgroundGliomas are the most frequent type of central nervous system tumor, accounting for more than 70% of all malignant CNS tumors. Recent...
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Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
BackgroundGrade 4 glioma is the most aggressive and currently incurable brain tumor with a median survival of one year in adult patients. Elucidating...
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Purinergic Signaling in Brain Tumors
Brain tumors are primary or metastatic tumors that proliferate in the brain tissue itself or surrounding tissues, such as pituitary and pineal...
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ARPC5 acts as a potential prognostic biomarker that is associated with cell proliferation, migration and immune infiltrate in gliomas
BackgroundGliomas are the most common malignant brain tumors, with powerful invasiveness and an undesirable prognosis. Actin related protein 2/3...
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Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy
Gliomas are the most common primary tumors of the central nervous system, with approximately half of patients presenting with the most aggressive...
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Glutamate in the Pathogenesis of Gliomas
Recent studies have shown that glutamate may serve important roles in the pathobiology of primary brain tumors. Glutamate is produced and secreted...
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Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders
HOX transcript antisense intergenic RNA ( HOTAIR ) is a long non-coding RNA (lncRNA) which is increasingly being perceived as a tremendous molecular...
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Glutamate in the Pathogenesis of Gliomas
Recent studies have shown that glutamate may serve important roles in the pathobiology of primary brain tumors. Glutamate is produced and secreted...
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The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses
Glioblastoma (GBM) comprises 45.6% of all primary malignant brain cancers and is one of the most common and aggressive intracranial tumors in adults....
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Cell Cycle-Related FAM64A Could be Activated by TGF-β Signaling to Promote Glioma Progression
Gliomas are aggressive brain tumors characterized by uncontrolled cell proliferation. FAM64A, a cell cycle-related gene, has been found to promote...
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Neuron-Cancer Synaptic and Other Electrical Signaling
Cancers survive by recapitulating mechanisms of normal development. Neuronal activity has been well established as the master regulator of...
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The Critical Role of RNA m6A Methylation in Gliomas: Targeting the Hallmarks of Cancer
Gliomas are the most common central cancer with high aggressive-capacity and poor prognosis, remaining to be the threat of most patients. With the...
