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Population pharmacokinetic modeling and simulation of choline in healthy Korean subjects after oral administration of choline alfoscerate
PurposeThis study aimed to investigate clinical pharmacokinetics (PKs) of choline after oral administration of choline alfoscerate capsule and newly...
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Liquid-filled hard capsule formulation of choline alfoscerate: preparation and in vitro/in vivo evaluation
PurposeThe objective of this study was to develop a liquid-filled hard capsule (LFHC) formulation of choline alfoscerate (CA) by screening with empty...
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Selection of Neuroprotective Therapy in Patients with Chronic Cerebral Ischemia Taking Account of the Synergism of Drug Interactions
Objective. To optimize selection of neuroprotective treatment protocols in patients with chronic cerebral ischemia taking account of synergism in...
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Effects of Baclofen on Central Paroxysmal Positional Downbeat Nystagmus
Paroxysmal positional nystagmus frequently occurs in lesions involving the cerebellum, and has been ascribed to disinhibition and enhanced canal...
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Stress, Asthenia, and Cognitive Disorders
Asthenia is a clinical syndrome that can be manifest in almost all somatic, infectious, and neurological diseases. Initially a protective mechanism...
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Strategies for develo** Alzheimer’s disease treatments: application of population pharmacokinetic and pharmacodynamic models
BackgroundAs the number of Alzheimer's disease (AD) patients steadily increases, many pharmaceutical industries and researchers are making efforts...
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Extensive frontal focused ultrasound mediated blood–brain barrier opening for the treatment of Alzheimer’s disease: a proof-of-concept study
BackgroundFocused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening has shown efficacy in removal of amyloid plaque and improvement of...
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Post-Covid Asthenia Syndrome
Objectives. To evaluate the efficacy and safety of combination therapy for patients with post-COVID asthenia syndrome (AS) using the multicomponent...
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Studies of the Efficacy of Cereton in Mild Cognitive Impairment of the Amnestic Type Based on Testing Lipid Markers
Objectives. To determine the efficacy and safety of treatment with Cereton (alfoscerate) in patients with mild cognitive impairment syndrome (MCI)...
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Direct and Indirect Neurological Signs of COVID-19
Objective. To systematize the neurological manifestations of COVID-19. Materials and methods. A systematic computerized analysis of all currently...
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Recent Progress in the Treatment Strategies for Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurological ailment that affects older people and causes a steady decline in their cognitive function. The cognitive...
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Hyperventilation Increases the Randomness of Ocular Palatal Tremor Waveforms
Hyperventilation changes the extracellular pH modulating many central pathologies, such as tremor. The questions that remain unanswered are the...
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The Cholinergic Profile as a Target for Rational Therapy of Central Nervous System Diseases and Injuries
Objective. To conduct a comparative analysis of the clinical efficacy of cholinergic drugs and acetylcholinesterase inhibitors and their combinations...
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Safety and tolerability of donepezil 23 mg with or without intermediate dose titration in patients with Alzheimer’s disease taking donepezil 10 mg: a multicenter, randomized, open-label, parallel-design, three-arm, prospective trial
BackgroundHigh-dose donepezil is currently prescribed for patients with Alzheimer’s disease (AD) who showed poor or waning response to a lower dose...
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Regression of Poststroke Aphasia and Concomitant Nonspeech Syndromes Due to Courses of Restorative Therapy Including Intensive Speech Therapy
Objectives. To analyze clinical indicators and fMRI parameters associated with the therapeutic efficacy of courses of complex restorative therapy...
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Effects of Prenatal Seizures on Cognitive and Motor Performance in Mice Offspring (with Emphasis on BDNF and GDNF Levels)
Prenatal seizures in a mother’s organism exert adverse effects on offspring. We investigated the effects of exposure to prenatal seizures in utero on...
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Wernicke–Korsakov Syndrome
Objective. To study the characteristics of the diagnosis and treatment of non-alcoholic-related Wernicke–Korsakov syndrome (WKS). Materials and...
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Effects of Modifications of the Functional State of the Central Cholinergic System on Neurological Deficiency Related to Experimental Traumatic Brain Injury
Using a 100-point Todd scale, we examined the level of neurological deficiency in male albino rats subjected to dosed experimental traumatic brain...
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Molecular Basis of Cholinergic Changes in Autism Spectrum Disorders and Relevance for Treatment Interventions
The causes of autism are heterogeneous and still largely unknown. Cholinergic abnormalities are reported in molecular pathological studies conducted...
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The effects of dietary choline
Food intake can influence neuronal functions through different modulators expressed in the brain. The present review is a report through relevant...