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Propensity score-matched analysis comparing hippocampus-avoidance whole-brain radiotherapy plus simultaneous integrated boost with hippocampus‑avoidance whole-brain radiotherapy alone for multiple brain metastases-a retrospective study in multiple institutions
BackgroundThe optimal treatment for multiple brain metastases has been recently controversially discussed.This study was aimed to explore the...
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Retrospective study of hypofractionated stereotactic radiotherapy combined with whole brain radiotherapy for patients with brain metastases
Background and purposeTo evaluate the clinical outcomes of hypofractionated stereotactic radiotherapy (HFSRT) combined with whole brain radiotherapy...
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Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center
BackgroundBrain metastases (BM) are a common complication in advanced cancer patients, and extremely challenging to treat. Consequently, whole brain...
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May we routinely spare hippocampal region in primary central nervous system lymphoma during whole brain radiotherapy?
PurposeOne of the main limiting factors of whole-brain radiation therapy (WBRT) for primary central nervous system lymphoma (PCNSL) is the impairment...
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Prognostic impact of EGFR/ALK alterations in leptomeningeal metastasis from lung adenocarcinoma treated with whole-brain radiotherapy
The prognosis and prognostic factors of patients receiving whole-brain radiotherapy (WBRT) for leptomeningeal metastasis (LM) from lung...
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“sCT-Feasibility” - a feasibility study for deep learning-based MRI-only brain radiotherapy
BackgroundRadiotherapy (RT) is an important treatment modality for patients with brain malignancies. Traditionally, computed tomography (CT) images...
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Application of piecewise VMAT technique to whole-brain radiotherapy with simultaneous integrated boost for multiple metastases
PurposeThis study implemented a piecewise volumetric modulated arc therapy (P-VMAT) for realizing whole-brain radiation therapy (WBRT) with...
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Adding simultaneous integrated boost to whole brain radiation therapy improved intracranial tumour control and minimize radiation-induced brain injury risk for the treatment of brain metastases
BackgroundBrain metastases (BMs) are the most frequent intracranial tumours associated with poor clinical outcomes. Radiotherapy is essential in the...
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Neurocognition and mean radiotherapy dose to vulnerable brain structures: new organs at risk?
BackgroundChildren with brain tumors are at high risk of neurocognitive decline after radiotherapy (RT). However, there is a lack of studies on how...
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Analysis of the efficacy of upfront brain radiotherapy versus deferred radiotherapy for EGFR/ALK-positive non-small cell lung cancer with brain metastases: a retrospective study
BackgroundFor brain metastases (BMs) from EGFR/ALK -positive non-small cell lung cancer (NSCLC), the best time to administer tyrosine kinase...
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Fractionated stereotactic radiotherapy of brain metastases: results of a retrospective study
BackgroundLasting local control of brain metastases following stereotactic radiotherapy is becoming increasingly relevant since systemic treatment...
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Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization
BackgroundBrain metastasis is one of the main causes of recurrence and death in non-small cell lung cancer (NSCLC). Although radiotherapy is the main...
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Dose-effect relationship of linear accelerator based stereotactic radiotherapy for brain metastases
ObjectiveThe purpose of this study is to reveal the dose-effect relationship of linear accelerator (LINAC)-based stereotactic radiotherapy (SRT) in...
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Dosimetric and clinical analysis of pseudo-progression versus recurrence after hypo-fractionated radiotherapy for brain metastases
BackgroundThe main challenge in follow-up duration of patients with brain metastases after stereotactic radiotherapy is to distinguish between...
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Effects of whole-brain radiation therapy on the blood–brain barrier in immunocompetent and immunocompromised mouse models
BackgroundApproximately 20% of all cancer patients will develop brain metastases in their lifespan. The standard of care for patients with multiple...
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Glasgow prognostic score for assessing the efficacy of whole-brain radiation therapy in cases of recursive partitioning analysis class 2 and class 3 multiple brain metastases: a retrospective study
PurposeWhole-brain radiotherapy (WBRT) may not be beneficial for patients with brain metastases (BMs). The Glasgow Prognostic Score (GPS) is a...
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First-line treatment with TKI plus brain radiotherapy versus TKI alone in EGFR-mutated non-small cell Lung cancer with brain metastases: a systematic review and meta-analysis
BackgroundIt remains uncertain whether first-line treatment with upfront brain radiotherapy (RT) in combined with epidermal growth factor receptor...
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The role of whole-brain radiotherapy (WBRT) in primary central nervous system lymphoma: is it an alternative to ASCT for consolidation following HD-methotrexate based induction in low-income settings?
BackgroundPrimary central nervous system lymphoma (PCNSL) is a rare and aggressive malignancy. Although potentially curable, its prognosis remains...
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Single institutional outcomes of whole brain radiotherapy for metastatic melanoma brain metastases
BackgroundThe management of melanoma with brain metastases (MBM) is increasingly complex, especially given recent improvements in targeted agents,...
