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Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease all over the world. In the last decade, accumulating proofs have evidenced that...
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Inhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells
BackgroundTargeting glycolysis in cancer is an attractive approach for therapeutic intervention. 2-Deoxyglucose (2DG) is a synthetic glucose analog...
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Thioredoxin is a metabolic rheostat controlling regulatory B cells
Metabolic programming is important for B cell fate, but the bioenergetic requirement for regulatory B (B reg ) cell differentiation and function is...
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Salvianolic acid A attenuated myocardial infarction–induced apoptosis and inflammation by activating Trx
Myocardial infarction (MI) is a leading cause of mortality worldwide and it is urgent to discover effective therapies. In this study, the protective...
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Trx4, a novel thioredoxin protein, is important for Toxoplasma gondii fitness
BackgroundTo successfully replicate within the host cell, Toxoplasma gondii employs several mechanisms to overcome the host cell defenses and...
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TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target
Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant...
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The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control
Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of...
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Understanding the Functions of Longevity Genes in Drosophila
The fruit fly, Drosophila melanogaster, has been an excellent model organism to study aging and longevity. A number of genes affecting longevity have...
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Harnessing the ROS for Cancer Treatment
Cancer treatment remains one of the toughest challenges. The paradox role of reactive oxygen species (ROS) in different stages of cancer have...
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Cytotoxic and Radiosensitising Effects of a Novel Thioredoxin Reductase Inhibitor in Brain Cancers
The thioredoxin (Trx) system, a key antioxidant pathway, represents an attractive target for cancer therapy. This study investigated the...
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Neurobehavioral, neurotransmitter and redox modifications in Nauphoeta cinerea under mixed heavy metal (silver and mercury) exposure
Heavy metals are encountered in nature, and are used in several human endeavors, including in dental fillings. It is well known that the safety of...
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Maresin1 ameliorates MSU crystal-induced inflammation by upregulating Prdx5 expression
BackgroundMaresin1 (MaR1) is a potent lipid mediator that exhibits significant anti-inflammatory activity in the context of several inflammatory...
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Exploring the immune interactions between Oncomelania hupensis and Schistosoma japonicum, with a cross-comparison of immunological research progress in other intermediate host snails
Schistosomiasis, the second largest parasitic disease in the world after malaria, poses a significant threat to human health and causes public health...
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ROS Modulatory Role of HDAC Inhibitors in Cancer Cells
Histone deacetylase (HDAC) inhibitors represent a novel class of therapeutic agents for cancer treatment. These enzymes play a pivotal regulatory...
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Analysis of codon usage bias of thioredoxin in apicomplexan protozoa
BackgroundApicomplexan protozoa are a diverse group of obligate intracellular parasites causing many diseases that affect humans and animals, such as...
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Molecular characterization and immune efficacy of fructose-1,6-bisphosphate aldolase from Haemaphysalis longicornis (Acari: Ixodidae)
BackgroundTicks are obligate hematophagous ectoparasites that transmit a variety of pathogens to humans, wildlife and domestic animals. Vaccination...
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ROS Modulatory Role of HDAC Inhibitors in Cancer Cells
Histone deacetylase (HDAC) inhibitors represent a novel class of therapeutic agents for cancer treatment. These enzymes play a pivotal regulatory...
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Thioredoxin-1 Rescues MPP+/MPTP-Induced Ferroptosis by Increasing Glutathione Peroxidase 4
Parkinson’s disease (PD), a common neurodegenerative disease, is typically associated with the loss of dopaminergic neuron in the substantia nigra...
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Chrysophanol exerts a protective effect against Aβ25-35-induced Alzheimer’s disease model through regulating the ROS/TXNIP/NLRP3 pathway
BackgroundThe primary pathogenic factors of Alzheimer’s disease (AD) have been identified as oxidative stress, inflammatory damage, and apoptosis....
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A broadly protective vaccine against cutaneous human papillomaviruses
Skin colonization by human papillomavirus (HPV) is typically related to inconspicuous cutaneous infections without major disease or complications in...
