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Role of Amyloid Beta in Neurodegeneration and Therapeutic Strategies for Neuroprotection
The gradual loss of neurons’ structure and function in the central nervous system is known as neurodegeneration. It is a defining feature of several...
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Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease
Neurogenesis, crucial for brain resilience, is reduced in Alzheimer’s disease (AD) that induces astroglial reactivity at the expense of the...
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Multitask representations in the human cortex transform along a sensory-to-motor hierarchy
Human cognition recruits distributed neural processes, yet the organizing computational and functional architectures remain unclear. Here, we...
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Insulin and Insulin-Like Growth Factor-1 Associated Cancers
Insulin and insulin-like growth factor-1 are involved in key metabolic processes maintaining cellular and tissue metabolic homeostasis. Malfunction...
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Clinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis
BackgroundNonerythrocytic spectrin beta 1 (SPTBN1) is an important cytoskeletal protein that involves in normal cell growth and development via...
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Multilayer Microcapsules with Tailored Structures and Properties as Delivery Carriers for Drugs and Growth Factors
Multilayer microcapsules fabricated via the layer-by-layer (LbL) assembly method with tailored structures and functionalities are promising...
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Laplace Transform Based Modeling of Drug Delivery with Reversible Drug Binding in a Multilayer Tissue
ObjectiveDrug delivery from a drug-loaded device into an adjacent tissue is a complicated process involving drug transport through diffusion and...
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Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer
Tissue factor (TF) is a protein that plays a critical role in blood clotting, but recent research has also shown its involvement in cancer...
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Ultrastructural and Molecular Characterization of Platelet-derived growth factor Beta-Positive Leptomeningeal Cells in the Adult Rat Brain
The leptomeninges, referring to the arachnoid and pia mater and their projections into the perivascular compartments in the central nervous system,...
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Circulating TGF-β1 Levels: Linking Muscle and Trauma
Transforming growth factor-beta 1 (TGF-β1) is a multifunctional growth factor that plays a key role in a variety of human tissues. Three TGF-β1...
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RETRACTED ARTICLE: Combination Cancer Immunotherapy with Dendritic Cell Vaccine and Nanoparticles Loaded with Interleukin-15 and Anti-beta-catenin siRNA Significantly Inhibits Cancer Growth and Induces Anti-Tumor Immune Response
PurposeThe invention and application of new immunotherapeutic methods can compensate for the inefficiency of conventional cancer treatment...
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Characterization of a nuclear transport factor 2-like domain-containing protein in Plasmodium berghei
BackgroundPlasmodium lacks an mRNA export receptor ortholog, such as yeast Mex67. Yeast Mex67 contains a nuclear transport factor 2 (NTF2)-like...
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Comprehensive research into prognostic and immune signatures of transcription factor family in breast cancer
BackgroundBreast cancer (BRCA) is the most common malignancy with high morbidity and mortality in women, and transcription factor (TF) is closely...
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Cytokines and Chemokines in Tumor Growth and Progression
The significance of cytokines as signaling molecules, which has long been acknowledged, is expanding as a result of their connection to malignancies...
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Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth
PurposeAberrant activation of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases drives oncogenic signaling through its...
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Breast stiffness, a risk factor for cancer and the role of radiology for diagnosis
Over the last five decades, breast density has been associated with increased risk of develo** breast cancer. Mammographically dense breasts are...
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The Prevailing Role of Topoisomerase 2 Beta and its Associated Genes in Neurons
Topoisomerase 2 beta (TOP2β) is an enzyme that alters the topological states of DNA by making a transient double-strand break during the...
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Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer
BackgroundOvarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH...
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Circulating TGF-β1 Levels: Linking Muscle and Trauma
Transforming growth factor-beta 1 (TGF-β1) is a multifunctional growth factor that plays a key role in a variety of human tissues. Three TGF-β1...
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ZNF92, an unexplored transcription factor with remarkably distinct breast cancer over-expression associated with prognosis and cell-of-origin
Tumor phenotype is shaped both by transforming genomic alterations and the normal cell-of-origin. We identified a cell-of-origin associated...
