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Improved Aerosolization Stability of Inhalable Tobramycin Powder Formulation by Co-Spray Drying with Colistin
PurposeTobramycin shows synergistic antibacterial activity with colistin and can reduce the toxic effects of colistin. The purpose of this study is...
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Risk Factors Associated with Suboptimal Tobramycin Levels in the Medical Intensive Care Unit
BackgroundOptimal aminoglycoside dosing in critically ill patients represents a challenge for practitioners, especially in the medical intensive care...
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Tobramycin-loaded complexes to prevent and disrupt Pseudomonas aeruginosa biofilms
Carbohydrate-based materials are increasingly investigated for a range of applications spanning from healthcare to advanced functional materials....
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Tazobactam/ceftolozane and tobramycin combination therapy in extensively drug-resistant Pseudomonas aeruginosa infections in severe burn injury: a case report
BackgroundCombination therapy with tazobactam/ceftolozane (TAZ/CTLZ) and high-dose aminoglycosides has been reported to be efficacious in extensively...
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In vitro models to detect in vivo bile acid changes induced by antibiotics
Bile acid homeostasis plays an important role in many biological activities through the bile–liver–gut axis. In this study, two in vitro models were...
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Elution Profiles of Synthetic CaSO4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin
Backgrounds and ObjectivesThe use of local antibiotic delivery vehicles is common in the management of biofilm-related infections as they provide...
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Does Sample Size, Sampling Strategy, or Handling of Concentrations Below the Lower Limit of Quantification Matter When Externally Evaluating Population Pharmacokinetic Models?
Background and ObjectivesPrecision dosing requires selecting the appropriate population pharmacokinetic model, which can be assessed through external...
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Determining effects of nitrate, arginine, and ferrous on antibiotic recalcitrance of clinical strains of Pseudomonas aeruginosa in biofilm-inspired alginate encapsulates
BackgroundBiofilms play a role in recalcitrance and treatability of bacterial infections, but majority of known antibiotic resistance mechanisms are...
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Screening, Post-SELEX Optimization and Application of DNA Aptamers Specific for Tobramycin
Tobramycin (TOB) is an aminoglycoside antibiotic. The residue of TOB in animal-derived foods and environment will be harmful to human health, and...
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Near Elimination of In Vitro Predicted Extrathoracic Aerosol Deposition in Children Using a Spray-Dried Antibiotic Formulation and Pediatric Air-Jet DPI
PurposeThis study evaluated the in vitro aerosol performance of a dry powder antibiotic product that combined a highly dispersible tobramycin powder...
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Aminoglycosides
Aminoglycosides are derivatives of naturally occurring organisms, and several aminoglycosides have been introduced for clinical use since the...
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When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers?
AimsWhether and when glomerular filtration rate (GFR) in preterms catches up with term peers is unknown. This study aims to develop a GFR maturation...
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Antimicrobial use among paediatric inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program, 2017/2018
BackgroundAntimicrobial resistance threatens the ability to successfully prevent and treat infections. While hospital benchmarks regarding...
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Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study
PurposeTobramycin is an aminoglycoside antibiotic of which the 24 h exposure correlates with efficacy. Recently, we found that clearance of the...
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Clinical characteristics and drug susceptibility profiles of Mycobacterium abscessus complex infection at a medical school in Thailand
ObjectivesThis study investigated the differences in epidemiological and clinical data, and antimicrobial susceptibilities among different subspecies...
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Co-transfer of IncFII/IncFIB and IncFII plasmids mediated by IS26 facilitates the transmission of mcr-8.1 and tmexCD1-toprJ1
PurposeThis study aimed to characterise the whole-genome structure of two clinical Klebsiella pneumoniae strains co-harbouring mcr-8.1 and tmexCD1-toprJ1...
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Monitoring of tobramycin serum concentrations in selected critically ill patients receiving selective decontamination of the digestive tract: a retrospective evaluation
IntroductionSelective decontamination of the digestive tract (SDD) is a strategy in mechanically ventilated patients to reduce mortality. Treatment...
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LipNanoCar Technology – A Versatile and Scalable Technology for the Production of Lipid Nanoparticles
The extensive knowledge in the miniemulsion technique used in biocatalysis applications by the authors allowed the development of drug delivery...
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Drug Hypersensitivity Reactions in Patients with Cystic Fibrosis: Potential Value of the Lymphocyte Toxicity Assay to Assess Risk
BackgroundCystic fibrosis (CF) is a genetic disease characterized by multi-system dysfunction resulting in recurrent lung infections and progressive...
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Defining the Importance of Age-Related Changes in Drug Clearance to Optimizing Aminoglycoside Dosing Regimens for Adult Patients with Cystic Fibrosis
Background and ObjectiveThe number of adults living with cystic fibrosis (CF) has increased and will continue to do so with the approval of cystic...
